Enantioseparation by HPLC Using an Inorganic Chiral Mesoporous Silica with Highly-ordered Structure  

作　　者：PENG Bo FU Shiguo LI Yanxia ZHANG Junhui XIE Shengming LI Li LYU Yun DU AN Aihong CHEN Xuexian YUAN Liming 

机构地区：[1]Department of Chemistry,Yunnan Normal University,Kunming 650500,P.R.China

出　　处：《Chemical Research in Chinese Universities》2019年第6期978-982,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(Nos.21675141,21665028,91856123).

摘　　要：Highly-ordered inorganic chiral mesoporous silica(HOCMS)has attracted substantial interest in recent decades.High performance liquid chromatography(HPLC)is the most important approach for the separation of enantiomers and herein reported an HPLC chiral stationary phase composed of HOCMS.The column was fabricated by conventional high pressure slurry packing.Eighteen racemates,including alcohols,ketones,amines,aldehydes and organic acids,were resolved on the column.Good chiral separations of hydrobenzoin,metoprolol,propranolol hydrochloride,4-methyl-2-pentanol,omeprazole,2,2′-furoin and ketoprofen were obtained.The relative standard devi-ations for five replicate separations of racemates were 0.1%–0.16%for retention time and 1.73%–2.64%for peak areas.The results suggest that HOCMS is a promising candidate for preparation of chiral stationary phases for HPLC.

关 键 词：Highly-ordered INORGANIC CHIRAL MESOPOROUS silica CHIRAL stationary phase High performance liquid chromatography ENANTIOSEPARATION 

分 类 号：O62[理学—有机化学]