序贯放疗和巩固放疗对广泛期小细胞肺癌患者无进展生存期影响的对比研究  

A Comparative Study of the Effects of Sequential Chest Radiotherapy and Consolidated Radiotherapy on Progression-Free Survival in Patients with Extensive Small Cell Lung Cancer

作　　者：俞邓枝 付文华[1] 田洁[1] 张媛[1] YU Deng-Zhi;FU Wen-Hua;TIAN Jie;ZHANG Yuan(Radiotherapy Department of Tumor Center,Chaoyang Hospital,Huainan 232007,China)

机构地区：[1]淮南朝阳医院肿瘤中心放疗科

出　　处：《生物技术通讯》2019年第5期648-652,共5页Letters in Biotechnology

基　　金：安徽省自然科学青年基金（1608085QH215）

摘　　要：目的:比较序贯放疗和巩固放疗对广泛期小细胞肺癌(ES-SCLC)患者生存时间的影响。方法:以2013年3月~2016年6月我院收治的82例ES-SCLC患者作为研究对象,根据放疗时机分为序贯放疗组(n=41)(先进行2程化疗,治疗结束2~4周后进行放疗,然后再给予2程化疗)、巩固放疗组(n=41)(先进行4程化疗,治疗结束2~4周后进行放疗,化疗均采用一线EP方案),比较2组治疗期间毒副作用、无进展生存期(PFS)和总生存时间(OS)。结果:2组患者的白细胞减少、血小板减少和血红蛋白减少的发生率无统计学差异(P>0.05)。序贯放疗组中位PFS和1年PFS率分别为12.10个月、39.02%,而巩固放疗组分别为10.00个月、9.76%,组间比较差异显著(P<0.05)。序贯放疗组中位OS、1年生存率和2年生存率分别为18.50个月、81.24%、6.32%,而巩固放疗组分别为17.00月、80.89%、3.50%,组间比较无明显差异(P>0.05)。结论:对比巩固放疗方案,采用序贯治疗可以更好地延长广泛期小细胞肺癌患者的无进展生存期,改善晚期患者的生活质量。Objective:To compare the effects of sequential radiotherapy and consolidated radiotherapy on survival time of patients with extensive-stage small cell lung cancer(ES-SCLC).Methods:From March 2013 to June 2016,82 patients with ES-SCLC in our hospital were divided into sequential radiotherapy group(n=41)according to the timing of radiotherapy(two courses of chemotherapy first,two to four weeks after the end of treatment,then two courses of chemotherapy)and consolidation radiotherapy group(n=41)(four courses of chemotherapy first,and two to four weeks after the end of treatment).The side effects,recurrence,progression-free survival(PFS)and overall survival(OS)of the two groups during treatment were compared.Results:There was no significant difference in the incidence of leukopenia,thrombocytopenia and hemoglobin reduction between the two groups(P>0.05).There was no significant difference in the recurrence rate of intrathoracic tumors between the two groups within 2 years(26.83%vs 31.71%,P>0.05).The median PFS and 1-year PFS rates in the sequential radiotherapy group were 12.10 months and 39.02%,while those in the consolidated radiotherapy group were 10.00 months and 9.76%.There was a significant difference between the two groups(P<0.05).The median OS,1-year survival rate and 2-year survival rate in sequential radiotherapy group were 18.50 months,81.24%and 6.32%respectively,while those in consolidated radiotherapy group were 17.00 months,80.89%and 3.50%respectively.There was no significant difference between the two groups(P>0.05).Conclusion:Compared with the consolidation of radiotherapy,sequential therapy can better prolong the PFS of patients with ES-SCLC and improve the quality of life of patients with advanced disease.

关 键 词：序贯放疗 巩固放疗 广泛期小细胞肺癌 无进展生存期 

分 类 号：R730.5[医药卫生—肿瘤]