调强放疗联合顺铂同步化疗治疗局部中晚期宫颈癌的疗效及不良反应  

Observation on the Clinical Outcomes and Complications of Intensty-modulated Radiotherapy Combined with Cisplatin Concurrent Chemotherapy in Local Advanced Cervical Carcinoma Patients

作　　者：涂海燕[1] 曾四元[1] 刘安文[2] 章玲玲 刘雅雯 钟美玲[1] 胡玉玲[1] TU Haiyan;ZENG Siyuan;LIU Anwen(Jiangxi Maternal and Child Health Hospital,Nanchang,330000)

机构地区：[1]江西省妇幼保健院,330006 [2]南昌大学第二附属医院,330006

出　　处：《实用癌症杂志》2019年第12期2044-2047,共4页The Practical Journal of Cancer

基　　金：江西省卫健委课题(编号:20155548)

摘　　要：目的观察调强放疗联合同步顺铂(DDP)化疗治疗中晚期宫颈癌的临床疗效及不良反应。方法选取无淋巴结转移的局部中晚期宫颈癌患者120例,其中IMRT联合同步DDP化疗组60例,CRT联合DDP化疗组60例,观察两组患者的近期疗效和1,2年生存率。同时观察两组患者放疗的不良反应情况。结果IMRT组与CRT组近期总有效率(CR+PR)分别为100%、95%,差异无统计学意义(P>0.05)。IMRT组1、2年生存率分别为100%、86.7%,CRT组1、2年生存率分别为90%、78.3%,差异均有统计学意义(P<0.05),IMRT组晚期肠道反应发生率较CRT组低(P<0.05),同样骨髓抑制的发生率IMRT组较CRT组低,差异有统计学意义(P<0.05)。肠道急性反应发生率及膀胱急慢性反应的发生率比较差异均无统计学意义(P>0.05)。结论IMRT联合顺铂同步化疗在治疗中晚期宫颈癌中可以提高近期疗效及1,2年生存率,并且明显降低晚期肠道反应及骨髓抑制的发生率,值得临床进一步推广应用。Objective To assess the clinical outcomes and complications of intensity-modulated radiotherapy combined with cisplatin concurrent chemotherapy in the treatment of local advanced cervical cancer.Methods 120 local advanced cervical cancer patients without lymphnode metastasis were selected,including 60 patients with IMRT combined with DDP concurrent chemotherapy group and 60 patients with CRT combined DDP concurrent chemotherapy group.To compare the clinical outcomes and survival rate in both groups.At the same time,the complications of the 2 groups were observed.Results The recent total efficiency(CR+PR)of IMRT group and CRT group were 100 and 95,respectively,with no significant difference(P>0.05).The 1-or 2-year survival rates of IMRT group were 100%and 86.7%,respectively,and the 1-or 2-year survival rates of CRT group were 90%and 78.3%respectively.The differences were statistically significant(P<0.05).The incidence of late gastrointestinal reactions in IMRT group was lower than that of CRT group(P<0.05).The incidence of the same bone marrow suppression was lower in IMRT group than that of CRT group,and the difference was statistically significant(P<0.05).There were no significant differences between the incidence of acute intestinal reactions and the incidence of acute and late bladder reactions between the 2 groups(P>0.05).Conclusion IMRT combined with cisplatin concurrent chemotherapy can improve the 1-or 2-year survival rates in the treatment of local advanced cervical cancer and also can reduce the incidence of late gastrointestinal reactions and bone marrow suppression,which is worthy of further clinical application.

关 键 词：调强放疗 同步化疗 顺铂 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]