同步推量调强放疗在局部晚期非小细胞肺癌中的应用  

Application of Simultaneous Integrated Boost Intensity Modulated Radiotherapy in Locally Advanced Non-small Cell Lung Cancer

作　　者：尤静[1] 杨丹[1] 李东明[1] 姜蕾蕾[1] 余荣[1] 于会明[1] 徐博[1] 王维虎 石安辉[1] Jing YOU;Dan YANG;Dongming LI;Leilei JILANG;Rong YU;Huiming YU;Bo XU;Weihu WANG;Anhui SHI(Peking University Cancer Hospital and Institute,Beijing 100142,China)

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所放疗科恶性肿瘤发病机制及转化研究教育部重点实验室

出　　处：《中国肺癌杂志》2019年第11期696-701,共6页Chinese Journal of Lung Cancer

基　　金：北京市卫生和计划生育委员会适宜技术推广项目（No.2018-TG-47）资助~~

摘　　要：背景与目的局部晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的标准治疗方案为放疗联合化疗,但其生存仍不令人满意。随着调强放疗技术的发展,同步推量(simultaneous integrated boost,SIB)技术成为局部晚期NSCLC的研究方向。本研究拟探讨局部晚期NSCLC采用SIB调强放疗技术的有效性和安全性。方法回顾性分析北京大学肿瘤医院2015年6月-2018年12月采用SIB技术进行放疗的局部晚期NSCLC患者资料,采用Kaplan-Meier方法进行统计分析,分析其疗效、生存及治疗相关毒性。结果研究纳入93例患者,中位随访时间34.23个月,3年生存率、无进展生存率、无局部区域复发生存率和无远处转移生存率分别为53.0%、37.0%、50.5%和50.5%。3级放射性食管炎发生率为5.4%,≥3级放射性肺炎发生率为2.2%。结论局部晚期NSCLC采用SIB调强放疗技术安全有效。Background and objective The standard treatment for locally advanced non-small cell lung cancer(NSCLC)is radiotherapy concurrent with chemotherapy,but the survival was not satisfied.With the development of intensity modulated radiotherapy,simultaneous integrated boost technique(SIB)becomes the research direction of locally advanced NSCLC.The aim of this study is to investigate the efficacy and safety of SIB intensity modulated radiotherapy technique for locally advanced NSCLC.Methods We retrospectively reviewed the clinical data of locally advanced NSCLC who were treated with radiotherapy by SIB technique in Peking University Cancer Hospital from June 2015 to December 2018.Kaplan-Meier method was used for analysis.Results Ninty-three patients were included in the analysis.After a median follow-up of 34.23 months,3-year overall survival(OS),progression-free survival(PFS),local-recurrence free survival(LRFS)and metastasis free survival(MFS)rates were 53.0%,37.0%,50.5%and 50.5%,respectively.The incidence of grade≥3 esophagitis was 5.4%.There were 2(2.2%)patients experiencing grade≥3 radiation-related pneumonia.Conclusion Radiation with SIB intensity modulated radiotherapy technique is effective and safe for patients with locally advanced NSCLC.

关 键 词：肺肿瘤 同步推量 有效性 

分 类 号：R73[医药卫生—肿瘤]