静脉滴注单唾液四己糖神经节苷脂钠联合综合康复法对脑卒中偏瘫患者的疗效及对神经功能缺损评分的影响  

Therapeutic effect of intravenous drip of MTG combined comprehensive rehabilitation on patients with stroke hemiplegia and its impact on neurologic impairment score

作　　者：李炳桦[1] 张媛媛[1] 安晓杰[2] 张霞 和金玲[3] 杨大福 LI Bing-hua;ZHANG Yuan-yuan;AN Xiao-jie;ZHANG Xia;HE Jin-ling;YANG Da-fu(Department of Rehabilitative Medicine,261 st Hospital of Chinese PLA,Beijing,100094,China)

机构地区：[1]解放军第261医院康复医学科,北京市100094 [2]解放军第261医院超声科,北京市100094 [3]解放军第261医院门诊部,北京市100094

出　　处：《心血管康复医学杂志》2019年第6期698-702,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨静脉滴注单唾液四己糖神经节苷脂钠(申捷)联合综合康复法对脑卒中偏瘫患者的疗效及对患者神经功能缺损评分的影响。方法:我院的脑卒中偏瘫患者100例,被随机均分常规治疗组(采用作业疗法、运动疗法等常规综合训练治疗)和联合治疗组(在常规治疗组的基础上联合静脉滴注申捷),连续治疗4周。对比两组患者的肢体、神经功能以及生活质量的差异。结果:治疗后8周,联合治疗组肢体功能治疗总有效率显著高于常规治疗组(94.0%比76.0%,P=0.030);治疗1周、4周和8周后,随着时间延长,两组格拉斯哥昏迷评分(GCS)均显著升高,且联合治疗组均显著高于常规治疗组[1周(8.56±2.47)分比(7.24±2.01)分,4周(11.26±2.81)分比(9.23±2.01)分,8周(13.28±3.43)分比(11.43±2.65)分],P均<0.01;治疗8周后,两组生活质量评分各项维度评分均较治疗前均显著提高,且联合治疗组各维度评分均显著高于常规治疗组(P均=0.001)。结论:静脉滴注申捷联合综合康复法对脑卒中偏瘫患者效果显著,能显著改善肢体功能及神经功能状态,并提高生活质量。Objective:To discuss therapeutic effect of intravenous drip of monosialic tetrahexose ganglioside(MTG)combined comprehensive rehabilitation on patients with stroke hemiplegia and its impact on neurologic impairment score(NIS).Methods:A total of 100 patients with stroke hemiplegia treated in our hospital were randomly and equally divided into routine treatment group(received routine comprehensive training treatment including work therapy,exercise therapy etc.)and combined treatment group(received intravenous drip of MTG based on routine treatment group),both groups were continuously treated for four weeks.Limb and neurologic function,and improvement of quality of life(QOL)were compared between two groups.Results:Oneight weeks after treatment,total effective rate of limb function in combined treatment group was significantly higher than that of routine treatment group(94.0%vs.76.0%,P=0.030);after one,four and eight-week treatment,along with time went on,there was significant rise in Glasgow coma scale(GCS)score in two groups,and those of combined treatment group were significantly higher than those of routine treatment group[one week:(8.56±2.47)scores vs.(7.24±2.01)scores,four weeks:(11.26±2.81)scores vs.(9.23±2.01)scores,eight weeks:(13.28±3.43)scores vs.(11.43±2.65)scores],P<0.01 all;compared with before treatment,there were significant rise in each dimension score of QOL in two groups after eight-week treatment,and each dimension score of combined treatment group was significantly higher than that of routine treatment group,P=0.001 all.Conclusion:Intravenous drip of MTG combined comprehensive rehabilitation possesses significant therapeutic effect on patients with stroke hemiplegia.It can significantly improve limb and neurologic function state,improve quality of life in these patients.

关 键 词：卒中 偏瘫 糖苷神经鞘脂类 

分 类 号：R743.3309[医药卫生—神经病学与精神病学]