颈动脉粥样硬化与老年脑梗死患者的相关性研究  

Correlation between carotid atherosclerosis and elderly patients with cerebral infarction

作　　者：马小秀 鲁建华[2] MA Xiaoxiu;LU Jianhua(Department of Health and Physical Examination,,Xianning Central Hospital/First Affiliated Hospital of Hubei University of Science and Technology,Xianning 437000,China;Department of Neurology,Xianning Central Hospital/First Affiliated Hospital of Hubei University of Science and Technology,Xianning 437000,China)

机构地区：[1]咸宁市中心医院湖北科技学院附属第一医院健康体检科,湖北咸宁437000 [2]咸宁市中心医院湖北科技学院附属第一医院神经内科,湖北咸宁437000

出　　处：《中国实用神经疾病杂志》2019年第20期2210-2216,共7页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨颈动脉粥样硬化与老年脑梗死患者的相关性。方法收集2015-03-2017-03在咸宁市中心医院神经内科住院的首次脑梗死患者60例为研究组,同时收集同期体检中心健康体检者60例为对照组,利用高频超声技术检测并记录2组颈动脉内-中膜厚度(IMT)、粥样斑块形态、管腔狭窄程度。结果脑梗死患者中22例IMT增厚,IMT平均厚度(1.06±0.86)mm,2组IMT增厚数目比较差异无统计学意义(P>0.05),但研究组患者IMT厚度明显高于对照组,差异有统计学意义(P<0.01);脑梗死患者中34例斑块形成,其中不稳定斑块19例,研究组斑块形成及不稳定斑块发生数均明显高于对照组,差异有统计学意义(P<0.05);脑梗死患者中18例出现颈动脉中重度狭窄,而对照组只有7例出现管腔中重度狭窄,2组比较差异有统计学意义(P<0.05)。结论颈动脉粥样硬化是脑梗死的重要危险因素,颈动脉内-中膜显著增厚、存在不稳定斑块及中重度狭窄的患者更易出现脑梗死。Objective To investigate the correlation between carotid atherosclerosis and elderly patients with cerebral infarction.Methods A total of 60 patients with first-episode cerebral infarction who were admitted to the Department of Neurology,Xianning Central Hospital from March 2015 to March 2017 were enrolled as the study group.60 healthy subjects from the same physical examination center were collected as control group,which were detected and recorded by high-frequency ultrasound technique.Carotid intima-media thickness(IMT),atheromatous plaque morphology,and luminal stenosis.Results Twenty-two patients with cerebral infarction had thickened IMT,and the mean thickness of IMT was(1.06±0.86) mm.There was no significant difference in the number of IMT thickening between the two groups(P>0.05),but the thickness of IMT in the study group was significantly higher than that in the control group.The difference was statistically significant(P<0.01);34 cases of plaque were formed in patients with cerebral infarction,including 19 cases of unstable plaque.The number of plaque formation and unstable plaques in the study group were significantly higher than those in the control group.Statistically significant(P<0.05);18 patients with cerebral infarction had severe carotid stenosis,while only 7 patients in the control group had severe stenosis in the lumen.The difference between the two groups was statistically significant(P<0.05).Conclusion Carotid atherosclerosis is an important risk factor for cerebral infarction.Patients with significant carotid-intimal thickening,unstable plaque and moderate to severe stenosis are more likely to develop cerebral infarction.

关 键 词：脑梗死 颈动脉粥样硬化 颈动脉狭窄 不稳定斑块 颈动脉内-中膜增厚 

分 类 号：R743.33[医药卫生—神经病学与精神病学]