急性脑梗死患者血清超敏C反应蛋白 降钙素原及白介素-6的检测意义  

Significance of detection of serum high-sensitivity C-reactive protein and procalcitonin and interleukin-6 in patients with acute cerebral infarction

作　　者：张素爱 宋春洪 储燕 ZHANG Suai;SONG Chunhong;CHU Yan(Department of Neurology,Huai'an Hospital,Huai'an 223200,China)

机构地区：[1]淮安市淮安医院神经内科

出　　处：《中国实用神经疾病杂志》2019年第20期2276-2280,共5页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨血清超敏C反应蛋白(hs-CRP)、降钙素原(PCT)和白介素-6(IL-6)在急性脑梗死(ACI)诊断中的价值。方法选取淮安市淮安医院神经内科收治的100例ACI患者为实验组,对照组为同期来院的50例健康体检者,分别测定2组血清hs-CRP、PCT和IL-6水平,并对实验组不同预后患者的hs-CRP、PCT及IL-6水平进行分析对比。结果实验组血清hs-CRP、PCT及IL-6水平均显著高于健康对照组(P<0.01);与实验组入院当天相比,入院后第1天hs-CRP、IL-6水平差异有统计学意义(P<0.05),至入院后第4天hs-CRP、PCT及IL-6水平差异均有统计学意义(P<0.01),至入院后第7天hs-CRP、PCT水平差异仍有统计学意义(P<0.05);死亡组与无变化组hs-CRP、PCT及IL-6水平明显高于进步组与显著进步组,差异有统计学意义(P<0.01)。结论动态监测血清hs-CRP、PCT及IL-6的水平对ACI的诊断、病情程度判断和预后评估具有重要的临床价值。Objective To investigate the value of serum high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT) and interleukin-6(IL-6) in the diagnosis of acute cerebral infarction(ACI).Methods 100 ACI patients admitted to the Department of Neurology,Huai’an Hospital of Huai’an City were selected as the experimental group,and the control group was 50 healthy patients who were admitted to the hospital during the same period.Serum hs-CRP,PCT and IL-6 levels were measured in the two groups.The levels of hs-CRP,PCT and IL-6 in patients with different prognosis were analyzed and compared.Results The serum hs-CRP,PCT and IL-6 levels in the experimental group were significantly higher than those in the healthy control group(P<0.01).Compared with the experimental group on the day of admission,the levels of hs-CRP and IL-6 on the first day after admission were different.Statistical significance(P<0.05),hs-CRP,PCT,and IL-6 levels were all significantly different on the 4 th day after admission(P<0.01),hs-CRP,PCT levels were different on the 7 th day after admission.There was still statistical significance(P<0.05);hs-CRP,PCT,and IL-6 levels in the death group and the unchanged group were significantly higher than those in the progress group and the significant progress group,and the differences were statistically significant(P<0.01).Conclusion Dynamic monitoring of serum hs-CRP,PCT and IL-6 levels has important clinical value for the diagnosis of ACI,the judgment of disease severity and the evaluation of prognosis.

关 键 词：急性脑梗死 超敏C反应蛋白 降钙素原 白介素-6 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学]