子宫内膜癌中微卫星不稳定性的临床病理意义  

Clinicopathologic Significance of Microsatellite Instability in Endometrial Carcinoma

作　　者：董晓峰[1] 蒋欣[2] 张建斌[1] DONG Xiao-feng;JIANG Xin;ZHANG Jian-bin(Department of Pathology,Lianyungang Hospital of Traditional Chinese Medicine,Lianyungang 222000,China;Department of Pathology,Lianyungang Maternal and Child Health Hospital,Lianyungang 222000,China)

机构地区：[1]连云港市中医院病理科,江苏连云港222000 [2]连云港市妇幼保健院病理科,江苏连云港222000

出　　处：《中国医药指南》2019年第32期6-7,共2页Guide of China Medicine

摘　　要：目的探讨子宫内膜癌的微卫星不稳定性及其临床病理意义。方法选取子宫内膜样腺癌45例利用免疫组化法检测MLH1、MSH2、MSH6以及PMS2错配修复蛋白的表达。结果45例子宫内膜样腺癌中,MMR表达缺失14例占31.1%,MSI-H的发生率28.9%。MSI-H组,中-低分化(10例,占76.9323%),高分化(3例,占23.077%)。结论MSI-H患者的临床病理特征与MSS/MSI-L患者有显著差异,检测子宫内膜癌的卫星不稳定状态在肿瘤的预防和进行临床治疗指导上具有重要作用。Objective To investigate the microsatellite instability of endometrial carcinoma and its clinicopathological significance.Methods Fortyfive patients with endometrioid adenocarcinoma were selected for the expression of mismatch repair proteins in MLH1,MSH2,MSH6 and PMS2 by immunohistochemistry.Results Of the 45 cases of endometrioid adenocarcinoma,14 cases of MMR were absent,accounting for 31.1%.The incidence of MSI-H was 28%.MSI-H endometrioidadenocarcinoma patients were poorly differentiated and moderately differentiated(10 cases,accounting for 76.923%),highly differentiated(3 cases,accounting for 23.077%).Conclusion The clinicopathological features of patients with MSI-H endometrial carcinoma are significantly different from those of patients with MSS/MSI-L endometrial carcinoma.Detection of satellite instability in endometrial cancer play an important role in tumor prevention and clinical treatment guidance.

关 键 词：子宫内膜癌 错配修复蛋白 微卫星不稳定 

分 类 号：R737.33[医药卫生—肿瘤]