盐酸多奈哌齐联合高压氧治疗血管性认知障碍疗效观察  

Clinical observation of donepezil hydrochloride combined with hyperbaric oxygen in the treatment of vascular cognitive impairment

作　　者：姜广亚[1] 娄季宇[2] 杨霄鹏[2] 张明[3] JIANG Guangya;LOU Jiyu;YANG Xiaopeng;ZHANG Ming(Department of Neurology,Yellow River Central Hospital,Yellow River Water Resources Commission,Zhengzhou 450003,China;Department of Neurology,Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,China;Department of Community,Yellow River Central Hospital,Yellow River Water Resources Commission,Zhengzhou 450003,China)

机构地区：[1]黄河水利委员会黄河中心医院神经内科,河南郑州450003 [2]郑州大学第二附属医院神经内科,河南郑州450003 [3]黄河水利委员会黄河中心医院社区科,河南郑州450003

出　　处：《中国实用神经疾病杂志》2019年第22期2498-2503,共6页Chinese Journal of Practical Nervous Diseases

基　　金：河南省医学科技攻关计划项目(编号:201503089)

摘　　要：目的探讨盐酸多奈哌齐联合高压氧治疗血管性认知障碍临床疗效。方法将存在血管性认知障碍的90例患者随机分为治疗组(n=47例)和对照组(n=43例),对照组给予多奈哌齐及脑血管病基础治疗,治疗组在对照组基础上联合高压氧物理治疗,观察治疗前后MMSE及MoCA评分变化。结果治疗前存在不同程度认知障碍,但MMSE及MoCA评分比较差异无统计学意义,治疗后2组认知功能均改善,MMSE及MoCA评分均提高,与对照组比较治疗组评分显著提高,2组比较差异有统计学意义(P<0.05)。结论血管性认知障碍患者在常规血管病及多奈哌齐治疗基础上联合高压氧物理治疗,能显著改善患者认知障碍,且无明特殊不良反应,安全有效,实用范围广。Objective To investigate the clinical efficacy of donepezil hydrochloride combined with hyperbaric oxygen in the treatment of vascular cognitive impairment.Methods Ninety patients with vascular cognitive impairment were randomized into a treatment group(47 patients) and a control group(43 patients).The control group received the basic treatment of donepezil and cerebrovascular disease.The treatment group was combined with hyperbaric oxygen physiotherapy on the basis of the control group.The changes of MMSE and MoCA scores before and after treatment were observed in the two groups.Results There were different degrees of cognitive impairment in the two groups before treatment,but there was no significant difference in MMSE and MoCA scores between the two groups.The MMSE and MoCA scores in two groups were all increased after the treatments and the cognitive function of the two groups were also improved,but the score of the treatment group increased significantly.The difference between the two groups after treatment was statistically significant.Conclusion For patients with vascular cognitive impairment,combined with hyperbaric oxygen physiotherapy on the basis of conventional vascular disease and donepezil treatment,it can significantly improve the cognitive impairment of patients,and has no specific adverse reactions,it is safe and effective,and has a wide range of practical applications.

关 键 词：血管性认知障碍 盐酸多奈哌齐 高压氧 危险因素 简易精神状态量表 蒙特利尔认知评估量表 缺血缺氧 胆碱酯酶 

分 类 号：R749.13[医药卫生—神经病学与精神病学]