2型糖尿病患者健康体检中幽门螺杆菌检查的必要性分析  

Analysis in necessity of Helicobacter pylori infection screening in healthy physical examinations of patients with type 2 diabetes mellitus

作　　者：崔乐乐[1] 卢金婧[1] 张耐思 裴冬梅[1] CUI Lele;LU Jinjing;ZHANG Naisi;PEI Dongmei(Physical Examination Center,Shengjing Hospital Affiliated to China Medical University,Shenyang,Liaoning,110004)

机构地区：[1]中国医科大学附属盛京医院体检中心

出　　处：《实用临床医药杂志》2019年第24期55-57,共3页Journal of Clinical Medicine in Practice

基　　金：美国中华基金会CMB(China Medical Board)项目(15-219)

摘　　要：目的探讨2型糖尿病患者健康体检中幽门螺杆菌(Hp)检查的必要性.方法采用^14 C尿素酶呼气实验方法检测1897例2型糖尿病患者、750例空腹血糖受损患者、800例非糖尿病对照组体检者的Hp感染情况并进行比较,并将1004例糖尿病患者根据Hp感染情况分为感染亚组及非感染亚组,比较2组患者的血糖、血脂差异.结果2型糖尿病患者的Hp感染阳性率为47.8%,空腹血糖受损患者的Hp感染阳性率为41.6%,均高于非糖尿病对照组体检者的34.8%,差异有统计学意义(P<0.01);2型糖尿病患者中Hp感染亚组及非感染亚组间的空腹血糖、血清总胆固醇、低密度脂蛋白胆固醇、甘油三脂、高密度脂蛋白胆固醇比较,差异有统计学意义(P<0.05).结论2型糖尿病患者更容易感染Hp,Hp感染对2型糖尿病的血糖、血脂代谢可能有一定影响,本研究提示对2型糖尿病患者进行Hp检测是有一定意义的.Objective To investigate Helicobacter pylori(Hp)infection screening in healthy physical examinations of patients with type 2 diabetes mellitus.Methods The Hp infection conditions of 1897 cases with type 2 diabetes,750 cases with impaired fasting glucose and 800 healthy controls were detected and compared by exhale urease breath test method.Out of these patients,1004 cases with type 2 diabetes were divided into Hp infection sub-group and Hp non-infection sub-group.Differences of blood glucose and blood lipid were compared between the two groups.Results Hp infection positive rate in type 2 diabetes mellitus patients and those with impaired fasting glucose were 47.8%,41.6%,respectively,which were significantly higher than 34.8%in the control group.There were significant differences in fasting blood glucose,serum total cholesterol,low-density lipoprotein cholesterol,triglyceride and high-density lipoprotein cholesterol between HP infected and non-infected subgroups(P<0.05).Conclusion Type 2 diabetes mellitus patients are more likely to be infected with by Hp,and it may impact on glucose and lipid metabolism in patients with type 2 diabetes.Therefore,it is of great significance to detect Hp in type 2 diabetic patients.

关 键 词：2型糖尿病 幽门螺杆菌 空腹血糖 血脂 体检 

分 类 号：R587.1[医药卫生—内分泌]