促红细胞生成素联合甲强龙对脊髓损伤病人神经功能的影响  

Effects of erythropoietin combined with methylprednisolone on neurological function in patients with spinal cord injury

作　　者：赵雅娜[1] 刘伟[1] 窦秀云 赵红 魏洁 张莉 李翠花[1] 窦玲云[1] ZHAO Ya-na;LIU Wei;DOU Xiu-yun;ZHAO Hong;WEI Jie;ZHANG Li;LI Cui-hua;DOU Ling-yun(Department of Orthopaedics,Tangshan Municipal Second Hospital,Tangshan 063000,China)

机构地区：[1]唐山市第二医院骨科

出　　处：《中国临床神经外科杂志》2019年第12期737-739,共3页Chinese Journal of Clinical Neurosurgery

基　　金：河北省医学科学研究重点课题计划项目(20181278)

摘　　要：目的探讨促红细胞生成素(EPO)联合甲强龙对脊髓损伤(SCI)病人神经功能的影响。方法回顾性分析2018年1~12月收治的60例SCI的临床资料。采用EPO联合甲强龙治疗30例(观察组),单用甲强龙治疗30例(对照组)。甲强龙首次用量30 mg/kg,在15 min内静脉注射,1 h后以5.4 mg/(kg·h)维持治疗24 h后;EPO治疗,3000 IU/次,3次/周,持续8周。治疗前及治疗后1个月按照美国脊髓损伤协会(ASIA)评分评估神经功能,采用日常生活活动能力(ADL)评分评估生活能力。治疗前、治疗后2周检测红细胞和血红蛋白水平,准确记录两组病人治疗2周内并发症情况。结果治疗前,两组ASIA评分、ADL评分、红细胞、血红蛋白水平均无统计学差异(P>0.05)。治疗后,两组ASIA评分、ADL评分、红细胞、血红蛋白水平均明显增高(P<0.05),而且,观察组明显高于对照组(P<0.05)。观察组并发症发生率明显低于对照组(P<0.05)。结论EPO联合甲强龙治疗有利于促进SCI病人神经功能的恢复,减少并发症,具有很好的临床疗效。Objective To explore the effects of erythropoietin(EPO)combined with methylprednisolone(MPS)on the neurological function in patients with spinal cord injury(SCI).Methods Sixty patients with SCI treated in our department from January to December,2018 were divided into control group in which 30 patients were treated by MPS and routine treatment and observed group in which 30 patients were treated by EPO on the basis of treatment given to the control group.The neurological function and prognosis were assessed respectively by American Spinal Cord Injury Association(ASIA)score and activities of daily living(ADL)score,and The levels of erythcyte and hemoglobinin(Hb)in the peripheral blood were determined 8 weeks after the treatment.Results The scores of ASIA and ADL,and the levels of erythrocyte and Hb in the peripheral blood were significantly higher in the observed group than those in the control group 8 weeks after the treatment(P<0.05).The incidence of respiratory tract infection and bacteremia were significantly lower in the observed group than those in the control group after the treatment(P<0.05).Conclusions The treatment with EPO combined with MPS can promote the recovery of neurological function and reduce the incidence of complications in the patients with SCI.

关 键 词：脊髓损伤 促红细胞生成素 甲强龙 神经功能 并发症 

分 类 号：R744.9[医药卫生—神经病学与精神病学]