超临界二氧化碳辅助制备β-环糊精-药物包合物的研究进展  

Preparation of β-cyclodextrin-drug Inclusion Complex Aided by Supercritical Carbon Dioxide

作　　者：王景昌[1,2] 赵宇 苗宏雨 赵启成 詹世平[1,2] WANG Jingchang;ZHAO Yu;MIAO Hongyu;ZHAO Qicheng;ZHAN Shiping(College of Environmental&Chemical Engineering,Dalian University,Dalian 116622;Chemical and Environmental Protection Engineering Research Technology Center,Dalian 116622)

机构地区：[1]大连大学环境与化学工程学院,大连116622 [2]辽宁省化工环保工程技术研究中心,大连116622

出　　处：《材料导报》2019年第S02期542-546,共5页Materials Reports

基　　金：国家自然科学基金(21676038)~~

摘　　要：β-环糊精是一种具有良好生物相容性的可降解生物材料,被广泛应用于医药、医疗和环境等领域。本文首先阐述了β-环糊精的基本性质及其在药剂学相关领域的应用,简要论述了超临界流体作为绿色溶剂的一些特点及其在药物制剂中的应用情况,介绍了超临界二氧化碳制备β-环糊精包合物的一些研究方法和结果,最后对β-环糊精的应用和超临界流体的研究发展方向进行了展望。Due to its good biocompatibility and biodegradability,β-cyclodextrin is widely used in the fields of the drug,medicine and environment and so on.In this paper,the basic properties ofβ-cyclodextrin and its application in pharmaceutical fields were described,and the characteristics of supercritical fluid as a green solvent and its application in pharmaceutical preparations were briefly discussed.Some research methods and results onβ-cyclodextrin inclusion complex prepared by supercritical carbon dioxide were introduced.Finally,the development direction on the application ofβ-cyclodextrin and the research of supercritical fluid were prospected.

关 键 词：Β-环糊精 超临界二氧化碳 Β-环糊精包合物 药物微粒 

分 类 号：TB34[一般工业技术—材料科学与工程]