免疫衰老在肿瘤及其免疫疗法中的研究进展  

Progress on Roles of Immunosenescence in Tumor Development and Immunotherapy

作　　者：谢泽萍[1] 文凤[1] 李纬[1] 陆惠 杨思霞 曾奕 曾婷[1] 程卫东[1] XIE Ze-ping;WEN Feng;LI Wei;LU Hui;YANG Si-xia;ZENG Yi;ZENG Ting;CHENG Wei-dong(School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510000,China)

机构地区：[1]南方医科大学中医药学院

出　　处：《中国肿瘤》2019年第12期934-940,共7页China Cancer

基　　金：国家重点研发计划(2018YFC1704404);广州市科技计划项目(201904010168);国家自然科学基金(81973641)

摘　　要：近年来许多国家和地区的肿瘤发病率和死亡率不断升高,人口结构老龄化是重要原因之一。肿瘤的发生率与年龄密切相关,除某些好发于儿童的肿瘤,大多数肿瘤在老年人中的发病率明显较高。肿瘤的发病被认为与免疫系统的衰老性改变相关。由于人体免疫系统具有强大的免疫监视功能,并且肿瘤的免疫疗法已得到广泛认可,免疫衰老学说对于解释老年人的肿瘤高发特性具有十分重要的意义。该文从免疫学的角度分析免疫衰老在肿瘤的发生发展和治疗中的作用,以便寻找更针对老年人群免疫特点的抗肿瘤对策,有助于发现肿瘤防治和预后改善的新途径。In recent years,the incidence and mortality of cancer in many countries and regions have been increasing,and population aging is one of the most important reasons.The incidence of cancer is closely related to age;except for some cancers that occur mostly in children,the incidence of most cancers is significantly higher among the elderly.The onset of tumors is thought to be strongly associated with senescence in the immune system.The immunesurveillance in the organism can clear mutated cells,and immunotherapy has been widely used for cancer treatment.The theory of immunosenescence can explain the high incidence of cancers in the elderly.The roles of immunosenescence in the development and treatment of tumors are reviewed in the article,to find new strategies for cancer prevention and treatment particularly for elderly population.

关 键 词：免疫衰老 肿瘤 免疫疗法 老年人 

分 类 号：R730.51[医药卫生—肿瘤]