视网膜光损伤与相关基因间作用的研究进展  

Progress in the study of the interaction between retinal light injury and related genes

作　　者：张秋丽 Zhang Qiuli(Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong 524000,China;Ophthalmology of the Affiliated Hospital of Inner Mongolia University of Nationalities,Tongliao,Inner Mongolia 028007,China;National University Of The Inner Mongol,Tongliao,Inner Mongolia 028007,China)

机构地区：[1]广东医科大学附属医院,广东湛江524000 [2]内蒙古民族大学附属医院眼科,内蒙古通辽028007 [3]内蒙古民族大学,内蒙古通辽028007

出　　处：《医药前沿》2019年第33期8-9,共2页Journal of Frontiers of Medicine

基　　金：蒙药古日古木-13通过miR-187调控RGC氧化应激的机制研究,国家自然基金(81660734);蒙药古日古木-13对青光眼RGC氧化应激的保护作用机制研究,内蒙古自然基金,2018MSO8118.

摘　　要：人体视觉功能的发挥有赖于视网膜这一重要器官,当其接收到光能的刺激之后、便会促使神经冲动、继而出现视觉.光是产生视觉信息的必要物质基础,但强烈的光照亦或是长时间的直视光源皆能够造成视网膜光损伤(light-induced retinal damage),诱发相关眼病.随着视频终端和眼科光学仪器的广泛使用,视网膜光损伤也越来越引起人们的重视.各国学者分别从不同角度对视网膜光损伤发生的机制和防治手段进行了深入研究.基于前人的研究成果,本文对网膜光损伤分子水平发病机制以及基因治疗方法进行综述.The function of the human visual function depends on the important organ of the retina.When it receives the stimulation of the light energy,it will cause the nerve impulse and then the vision.The light is the necessary material base for generating the visual information.However,the light-induced retinal damage can be caused by the intense illumination or the direct-view light source for a long time,so that the related eye diseases can be induced.With the extensive use of the video terminal and the ophthalmic optical instrument,the retinal light damage has also attracted more and more attention.The means of treatment have been deeply studied.Based on the previous research Results,the pathogenesis and gene therapy Methods of omentum light injury at molecular level are reviewed in this paper.

关 键 词：视网膜 光损伤 发病机制 基因治疗 

分 类 号：R774.1[医药卫生—眼科]