环氧化物酶-2在肿瘤微环境中的作用研究进展  

Research Progress on Roles of COX-2 in Tumor Microenvironment

作　　者：陈艺萍 潘建基 CHEN Yi-ping;PAN Jian-ji(Fujian Medical University Cancer Hospital,Fuzhou 350014,China)

机构地区：[1]福建医科大学附属肿瘤医院

出　　处：《肿瘤学杂志》2019年第11期990-994,共5页Journal of Chinese Oncology

基　　金：福建省自然科学基金(2019J01194;2018J01275)

摘　　要：肿瘤微环境是肿瘤赖以生存的环境,肿瘤细胞与所处的环境相互作用,形成有利于其发生发展的环境条件。肿瘤微环境的组分多元,包括各种细胞和因子,环氧化物酶-2就是其中的一种。环氧化物酶-2在多种实体瘤中存在高表达,并参与了肿瘤发生发展的众多环节,包括免疫逃逸、增殖、抗凋亡、转移等。全文就环氧化物酶-2在肿瘤微环境领域的研究进展进行综述。The tumor cells interact with their microenvironment,in which tumor growth is promoted. There are various active factors existing in the tumor microenvironment,COX-2 is one of them. Reports have shown that COX-2 is over-expressed in many solid tumors and involved in the process of tumorogenesis and progression,including immunologic escape,proliferation,anti-apoptosis and metastasis. This article reviews the research progress on the roles of COX-2 in the tumor microenvironment.

关 键 词：肿瘤微环境 环氧化物酶-2 免疫逃逸 增殖 凋亡 转移 

分 类 号：R730.231[医药卫生—肿瘤]