美多巴联合盐酸司来吉兰治疗帕金森病的疗效和安全性分析  

Analysis on the effect and saety of medopa combined with selegilan hydrochloride forthe treatment of Parkinson disease

作　　者：付经桥 Fu Jingqiao(Department of Neurology 2,Wafangdian Central Hospital,Dalian,Liaoning,116300,China)

机构地区：[1]瓦房店市中心医院神经内二科

出　　处：《当代医学》2019年第36期85-87,共3页Contemporary Medicine

摘　　要：目的临床研究美多巴联合盐酸司来吉兰治疗帕金森病的疗效和安全性分析。方法回顾性抽取与分析本院2016年9月至2018年9月收治的129例帕金森病患者,以不同的治疗方式将患者分为两组,美多巴组65例,采取单用美多巴药物方案治疗,联合组64例,采取美多巴联合盐酸司来吉兰治疗方案。分析组间相关指标变化意义。结果治疗前,两组患者运动功能评分、精神状态评分、日常活动能力评估比较,差异无统计学意义;治疗后,两组患者评分均改善,联合组患者评分优于美多巴组,差异具有统计学意义(P<0.05)。治疗后,联合组总有效率为90.77%,美多巴组为46.88%,两组差异具有统计学意义(P<0.05)。联合组不良反应发生率低于美多巴组,分别为15.38%、70.31%,差异具有统计学意义(P<0.05)。结论临床上应用美多巴联合盐酸司来吉兰治疗帕金森病,能显著缓解临床症状,患者接受度高,能够在临床逐渐开展应用。Objective To study the effect and safety of medopa combined with salicillamine hydrochloride for the treatment of Parkinson disease.Methods From September 2016 to September 2018,129 patients with Parkinson disease were analyzed retrospectively in our hospital,the patients were divided into medopa group(65 cases)and combined group(64 cases).There were 65 patients who were treated with medopa alone and 64 patients who were treated with medopa combined with salicillamine hydrochloride.The significance of the relative indexes change between groups was analyzed.Results Before treatment,there was no significant difference between the two groups in motor function score,mental state score and daily activity ability evaluation.After treatment,the scores of the two groups were improved,and the scores of the combined group were better than those of the medopa group(P<0.05).After treatment,the total effective rate was 90.77%in the combined group and 46.88%in the medoba group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the combined group was lower than that in the medoba group(15.38%,70.31%),the difference was statistically significant(P<0.05).Conclusion For the clinical treatment of Parkinson disease,the medopa combined with selegiline hydrochloride has a significant effect on the remission of symptoms and can be gradually applied in clinical practice.

关 键 词：美多巴 盐酸司来吉兰 帕金森病 临床疗效 安全性分析 

分 类 号：R74[医药卫生—神经病学与精神病学]