内镜逆行胰胆管造影介导光动力疗法治疗胆管癌研究进展  

Research progress in endoscopic retrograde cholangiopancreatography-mediated photodynamic therapy for cholangiocarcinoma

作　　者：王昆鹏[1,2] 熊力 张子建[1] 刘锴 黄云鹏 杨鑫 李清龙 陈伟[3] 邹恒[1] 文宇 WANG Kunpeng;XIONG Li;ZHANG Zijian;LIU Kai;HUANG Yunpeng;YANG Xin;LI Qinglong;CHEN Wei;ZOU Heng;WEN Yu(Department of General Surgery,Second Xiangya Hospital,Central South University,Changsha 410011;Department of General Surgery,Taizhou Central Hospital(Affiliated Hospital of Taizhou College),Taizhou Zhejiang 318000;Department of Physics,University of Texas,Arlington Texas 76019-0059,USA)

机构地区：[1]中南大学湘雅二医院普外科,长沙410011 [2]台州市中心医院(台州学院附属医院)普外科,浙江台州318000 [3]德克萨斯州大学物理系,美国德克萨斯州阿灵顿76019-0059

出　　处：《中南大学学报（医学版）》2019年第11期1275-1280,共6页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81970569,81773293,31660266);湖南省自然科学基金(2015JJ4083,2018JJ3758);湖南省重点研发计划(2017DK2011,2017WK2060,2015GK3117);湖南省中药研究项目(201869,201951);中南大学湘雅二医院基金~~

摘　　要：胆管癌恶性程度高,早期诊断困难,绝大多数患者被确诊时已不可行手术切除,患者生存质量低,生存周期短,传统放射治疗和化学药物治疗效果欠佳且不良反应大,因而缺乏有效的控制手段。内镜逆行胰胆管造影(endoscopic retrograde cholangiopancreatography,ERCP)是诊断和治疗胆道疾病的重要手段,而光动力疗法(photodynamic therapy,PDT)作为胆管癌的一种新的局部治疗方法优势明显。近年来,ERCP介导的PDT治疗胆管癌的研究在国外逐渐兴起。其可有效缓解胆管癌患者的症状,提高生存质量,延长生存期,有望成为治疗胆管癌的新手段。The malignant degree of cholangiocarcinoma is high,and the early diagnosis is difficult.The vast majority of patients are unresectable when they are diagnosed.The patients have low quality of life and short survival cycle.Traditional radiotherapy and chemotherapy have poor efficacy and lead to side effects,and thus lack effective control measures for cholangiocarcinoma.Endoscopic retrograde cholangiopancreatography(ERCP)is an important method for diagnosing and treating biliary tract diseases.Photodynamic therapy(PDT)is a new local treatment for cholangiocarcinoma.In recent years,ERCP-mediated PDT treatment of cholangiocarcinoma has gradually emerged.ERCPmediated PDT can effectively relieve the symptoms of patients with cholangiocarcinoma,improve the patients’quality of life,prolong the survival cycle,and is expected to become a new treatment for cholangiocarcinoma.

关 键 词：胆管癌 光动力疗法 内镜逆行胰胆管造影 

分 类 号：R73[医药卫生—肿瘤]