膀胱癌耐药和复发相关机制的研究进展  

Research progress in mechanisms for drug-resistance and recurrence in bladder cancer

作　　者：高鑫 张淑芳[1] GAO Xin;ZHANG Shufang(Central Laboratory,Affiliated Haikou Hospital of Xiangya School of Medicine,Central South University,Haikou 570208;Clinical Laboratory,First People’s Hospital of Huaihua,Huaihua Hunan 418000,China)

机构地区：[1]中南大学湘雅医学院附属海口医院中心实验室,海口570208 [2]怀化市第一人民医院检验科,湖南怀化418000

出　　处：《中南大学学报（医学版）》2019年第11期1287-1293,共7页Journal of Central South University ：Medical Science

摘　　要：膀胱癌是泌尿系统常见恶性肿瘤,其耐药和复发已成为临床治疗的一大难题。目前,临床上还十分缺乏有效预测膀胱癌耐药的分子标志物。膀胱癌耐药机制十分复杂,常见的耐药机制有基因表观遗传学修饰及表达水平异常、非编码RNA异常调节、膀胱癌干细胞的产生、药物外排增加和自噬等。膀胱癌的各种耐药机制间并不是相互独立的,而是存在一定的相互联系,共同导致耐药的发生。深入研究膀胱癌耐药机制对攻克耐药难题、寻找治疗监测标志物和治疗靶点有重要意义。Bladder cancer is a common malignant tumor in the urinary system,and its drug-resistant recurrence has become a major problem in clinical treatment.At present,there is still a lack of molecular markers for effectively predicting bladder cancer resistance.The mechanisms for drug resistance in bladder cancer is very complicated.The common mechanisms of drug resistance include epigenetic modification,abnormal expression level,abnormal regulation of non-coding RNA,production of bladder cancer stem cells,increase of drug efflux and autophagy.The various drug resistance mechanisms of bladder cancer are not independent,but there is a certain relationship between them,which leads to the occurrence of drug resistance.Further study on the mechanisms for bladder cancer resistance is of great importance to overcome these problems.

关 键 词：膀胱癌 耐药 复发 生物学标志物 治疗靶点 

分 类 号：R73[医药卫生—肿瘤]