4-二甲氨基吡啶促进的一锅法合成高选择性螺环丙烷吡唑啉酮衍生物（英文）  

High-Selective One-Pot Synthesis of Spirocyclopropane Pyrazolones Promoted by 4-Dimethylaminopyridine

作　　者：梁杰 马会芳 阿布拉江·克依木[1] Liang Jie;Ma Huifang;Ablajan Keyume(Key Laboratory of Oil&Gas Fine Chemicals,Ministry of Education&Xinjiang Uyghur Autonomous Region,College of Chemistry and Chemical Engineering,Xinjiang University,Urumqi 830046)

机构地区：[1]新疆大学化学化工学院石油天然气精细化工教育部&新疆维吾尔自治区重点实验室

出　　处：《有机化学》2019年第11期3169-3175,共7页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(Nos.21961038,21462041)~~

摘　　要：发展了一种4-二甲氨基吡啶(DMAP)促进的高立体选择性合成多取代螺环丙烷吡唑啉酮的方法.该反应以吡唑啉酮、芳醛和溴乙酸酯为原料, DMAP作为碱,经三组分一锅反应,合成一系列收率高且非对映选择性好的目标化合物.该反应具有操作简单、产率高以及非对映选择性好等优点.该合成方法对于螺环丙烷的研究具有重要的价值.A 4-dimethylaminopyridine(DMAP)-promoted high stereoselectivity method for the synthesis of polysubstituted spiropropane pyrazolone was developed. A series of target compounds were synthesized from using pyrazolone, aromatic aldehyde and bromoacetate as raw materials, and DMAP as a base with high yield via three-component one-pot reaction. This reaction has the advantages of simple operation, high yield and good diastereotopic selectivity. In addition, this synthetic method is of great value for the study of spiropropane.

关 键 词：一锅法合成 多组分反应 螺环丙烷 吡唑酮 4-二甲氨基吡啶(DMAP) 

分 类 号：O62[理学—有机化学]