High-Voltage-Activated Calcium Channel in the Afferent Pain Pathway: An Important Target of Pain Therapies  

作　　者：Qi Li Jian Lu Xiaoxin Zhou Xuemei Chen Diansan Su Xiyao Gu Weifeng Yu 

机构地区：[1]Department of Anesthesiology,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China [2]Department of Anesthesiology,The Second Affiliated Hospital of Jiaxing University,Jiaxing 314000,China

出　　处：《Neuroscience Bulletin》2019年第6期1073-1084,共12页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (81701092);Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Support (20171916);Shanghai Municipal Commission of Health and Family Planning Funding for Key Developing Disciplines (2015ZB0101)

摘　　要：High-voltage-activated(HVA) Ca^(2+)channels are widely expressed in the nervous system. They play an important role in pain conduction by participating in various physiological processes such as synaptic transmission, changes in synaptic plasticity, and neuronal excitability. Available evidence suggests that the HVA channel is an important therapeutic target for pain management. In this review, we summarize the changes in different subtypes of HVA channel during pain and present the currently available evidence from the clinical application of HVA channel blockers. We also review novel drugs in various phases of development. Moreover, we discuss the future prospects of HVA channel blockers in order to promote ‘‘bench-to-bedside'' translation.High-voltage-activated（HVA） Ca2+channels are widely expressed in the nervous system. They play an important role in pain conduction by participating in various physiological processes such as synaptic transmission, changes in synaptic plasticity, and neuronal excitability. Available evidence suggests that the HVA channel is an important therapeutic target for pain management. In this review, we summarize the changes in different subtypes of HVA channel during pain and present the currently available evidence from the clinical application of HVA channel blockers. We also review novel drugs in various phases of development. Moreover, we discuss the future prospects of HVA channel blockers in order to promote ‘‘bench-to-bedside’’ translation.

关 键 词：PAIN High-voltage-activated calcium channel Dorsal root ganglion 

分 类 号：R74[医药卫生—神经病学与精神病学]