含吗啉基片段的水杨醛席夫碱化合物的合成及其抗氧化活性  

Synthesis and Antioxidant Activity of Salicylaldehyde Schiff Base Containing Morpholine Fragments

作　　者：孙凤梅 胡正松 SUN Feng-mei;HU Zheng-song(School of Chemistry and Chemical Engineering,Huaiyin Normal University,Huai'an 223300,China)

机构地区：[1]淮阴师范学院化学化工学院

出　　处：《化学试剂》2019年第12期1239-1244,共6页Chemical Reagents

基　　金：江苏省高校自然科学基金资助项目(18KJD-150001)

摘　　要：以取代水杨醛和吗啉基苯胺缩合反应,合成了6个水杨醛席夫碱衍生物,其中3个是新化合物。其结构均经1HNMR、13CNMR、IR、LC-MS和元素分析确证。同时,通过X-单晶衍射分析,测定了2-{[(3-氟-4-吗啉苯基)亚氨基]甲基}苯酚的晶体结构,确证了化合物为稳定的E-式结构。初步测定了化合物对DPPH自由基的抗氧化活性,结果表明,所有化合物在测试浓度为0. 02~0. 10 g/L时都表现出一定的抗DPPH自由基活性。其中2-{[(3-氟-4-吗啉苯基)亚氨基]甲基}-6-甲氧基苯酚表现出优异的抗氧化活性,在不同浓度时对DPPH自由基的清除率都大于30%。Six derivatives of salicylaldehyde Schiff bases were synthesized by condensation reaction of substituted salicylaldehyde with morpholine aniline.The structures were confirmed by 1HNMR,13CNMR,IR,LC-MS and elemental analysis.At the same time,the crystal structure of 2-{[(3-fluoro-4-morpholinophenyl)imino]methyl}phenol was determined by X-ray diffraction analysis,and confirmed that the compound adopted the more stable E configuration.The antioxidant activity of the compounds against DPPH free radicals was preliminarily determined,and the results showed that all compounds exhibited certain activity against DPPH free radical in the range of 0.02~0.10 g/L.2-{[(3-Fluoro-4-morpholinophenyl)imino]methyl}-6-methoxyphenol exhibited excellent antioxidant activity,and the scavenging rate of DPPH radical was more than 30%at different concentrations.

关 键 词：吗啉 水杨醛 席夫碱 合成 抗氧化活性 

分 类 号：O625[理学—有机化学]