棕色脂肪组织与骨相互关系的研究进展  

Research progress on the mutual effects between brown adipose tissue and bone

作　　者：孙梦悦 袁琦 杨静蕾 张日东[1] 唐珊 陶沙[1] 毛莉[1] Sun Mengyue;Yuan Qi;Yang Jinglei;Zhang Ridong;Tang Shan;Tao Sha;Mao Li(Department of Endocrinology,The Affiliated Huaian No.1 People′s Hospital of Nanjing Medical University,Huaian 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院内分泌科,223300

出　　处：《中华内分泌代谢杂志》2019年第11期995-998,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：棕色脂肪组织(BAT)能够通过解耦联蛋白(UCP1)的作用将机体储存的能量直接以热量的形式散失,以此增加能量消耗.除此以外,棕色脂肪细胞可通过自分泌、旁分泌和内分泌机制调节机体代谢.近年来越来越多的研究表明,棕色脂肪组织与骨代谢有密切联系,BAT分泌多种因子调节骨代谢,同时骨骼也分泌多种生物活性物质调节BAT功能.另外,BAT还可能通过肌肉介导、调节SNS的活性、改善机体代谢状况间接参与骨代谢,从而形成BAT-骨骼轴.本文通过阐述两者之间的关系,探讨棕色脂肪组织与骨骼相互作用的机制.Brown adipose tissue(BAT)increases energy consumption by directly dissipating stored energy in the form of heat through the role of uncoupling protein(UCP1).Recent studies have found that brown adipocytes may also regulate metabolism through autocrine,paracrine,and endocrine mechanisms.A growing body of evidences have shown that the BAT has a close relationship with bone metabolism,in which BAT secretes a variety of factors to regulate bone metabolism,while bone also secretes a variety of bioactive substances to control BAT function.In addition,BAT may indirectly participate in bone metabolism through muscle-mediated regulation or SNS activity and improvement of body metabolism,thus forming a BAT-skeletal axis.In this paper,we try to explain the relationship between brown adipose tissue and bone,and to discuss their interactive mechanisms.

关 键 词：棕色脂肪 骨代谢 内分泌因子 

分 类 号：R73[医药卫生—肿瘤]