钆塞酸二钠肝脏增强多动脉期DISCO成像技术评价动脉晚期采集和图像质量与单动脉期对比研究  

Evaluation of multiple-arterial-phase aquisition and image quality in gadoxetate acid disodium enhanced liver MRI using differential sub-sampling with cartesian ordering technique:a comparative study with single arterial phase

作　　者：唐鹤菡[1] 魏毅[1] 邓莉萍[1] 袁元[1] 陈国勇[1] 魏小程 杨汉城 宋彬[1] Tang Hehan;Wei Yi;Deng Liping;Yuan Yuan;Chen Guoyong;Wei Xiaocheng;Yang Hancheng;Song Bin(Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China;MR Research Department,General Electric(China),Beijing 100176,China;MR Training Department,General Electric Medical Group,Beijing 100176,China)

机构地区：[1]四川大学华西医院放射科,成都610041 [2]通用电气(中国)磁共振科研部,北京100176 [3]通用电气医疗集团磁共振培训部,北京100176

出　　处：《中华放射学杂志》2019年第12期1071-1075,共5页Chinese Journal of Radiology

基　　金：国家自然科学基金(81771797)。

摘　　要：目的探讨基于笛卡尔采集的K空间共享三维容积快速动态成像(DISCO)多动脉期成像技术在钆塞酸二钠肝脏增强MRI上的应用价值.方法前瞻性收集2017年9月至2018年3月四川大学华西医院经超声或CT检查怀疑恶性局灶性肝脏病变的56例患者,术前均行钆塞酸二钠肝脏增强MRI检查.采用随机数字表法将患者分组,A组29例,采用DISCO技术行肝脏多动脉期成像;B组27例,采用肝脏容积快速采集联合两点法水脂分离(LAVA-Flex)序列行单动脉期成像,评价动脉晚期图像的显示率和动态增强图像的呼吸运动伪影.分类变量间比较采用χ2检验,单动脉期与多动脉期间呼吸运动伪影的比较采用Mann-Whitney U检验,多动脉期各时相间伪影评分的比较采用Kruskal-Wallis H检验.结果A组患者的DISCO序列中,96.6%(28/29)的患者观察到动脉晚期,高于采用LAVA-Flex采集的单动脉期成像[74.1%(20/27)],差异有统计学意义(χ2=5.770,P=0.016).在呼吸运动伪影的评价中,LAVA-Flex[3(3,4)]获得的动脉晚期图像的运动伪影较DISCO序列[2(2,3)]更严重,差异有统计学意义(Z=-3.250,P<0.01).DISCO序列6个期相运动伪影的评分中,第1、2、3、4、5和6期的伪影评分分别为[3(3,4)]、[2(2,3)]、[2(2,3)]、[3(2,3)]、[3(3,4)]和[3(3,4)]分,第2、3、4期的伪影评分明显优于第1、5、6期,差异有统计学意义(P<0.05),但第2、3、4期间差异均无统计学意义(P>0.05).结论相较于单动脉期成像,钆塞酸二钠肝脏增强DISCO多动脉期采集可提高动脉晚期采集效率并减少运动伪影.Objective To investigate the application value of multiple-arterial-phase imaging technique with differential sub-sampling with cartesian ordering(DISCO)in the gadoxetate acid disodium enhanced liver MRI.Methods From September 2017 to March 2018,56 patients with suspected malignant focal liver disease diagnosed with ultrasound or CT in West China Hospital of Sichuan University were enrolled prospectively,and underwent preoperative enhanced MRI with gadoxetate acid disodium.Patients were divided into 2 groups by random-number table method.Twenty nine patients in group A underwent liver multiple-arterial-phase imaging with DISCO.Twenty seven patients in group B underwent single-arterial-phase imaging with liver acquisition with volume acceleration-flex(LAVA-Flex).The display rate of late-arterial-phase and respiratory motion artifacts of dynamic enhancement images were evaluated.The categorical variables was compared by Chi-square test.The respiratory motion artifacts between the single-arterial-phase and multiple-arterial-phases were compared by Mann-Whitney U test.The artifact scores among the various phases of the multi-arterial phase were compared by Kruskal-Wallis H.Results Compared to LAVA-Flex[74.1%(20/27)],a higher display rate of late-arterial phase[96.6%(28/29)]was found in DISCO(Group A),and the difference was statistically significant(χ2=5.770,P=0.016).In the evaluation of respiratory motion artifacts,the motion artifacts of the late-arterial images obtained by LAVA-Flex[3(3,4)]were more severe than the DISCO[2(2,3)],and the difference was statistically significant(Z=-3.250,P<0.01).Among the scores of motion artifacts in the 6 phases of DISCO,the artifact scores of phase 1,2,3,4,5,6 were[3(3,4)],[2(2,3)],[2(2,3)],[3(2,3)],[3(3,4)]and[3(3,4)],respectively.The motion artifacts of phase 2,3,4 were better than phase 1,5,6,the differences were statistically significant(P<0.05),but there was no statistical differences among phase 2,3 and 4(P>0.05).Conclusion Compared with single-arterial-phase imaging,multip

关 键 词：肝脏 动脉晚期 磁共振成像 钆塞酸二钠 

分 类 号：R575[医药卫生—消化系统] R44[医药卫生—内科学]