基于维生素D轴探讨补肾治疗结直肠癌的潜在靶点  

Discussion on Potential Targets of Kidney-Tonifying Therapy for Colorectal Cancer Based on Vitamin D Axis

作　　者：张孟之 段亚平 王宗陵 任慧敏 高洁 柴艺汇 李文 秦忠 管连城 陈云志 ZHANG Mengzhi;DUAN Yaping;WANG Zongling;REN Huimin;GAO Jie;CHAI Yihui;LI Wen;QIN Zhong;GUAN Liancheng;CHEN Yunzhi(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,Guizhou,China;School of Nursing,Guizhou Vocational College of Industry and Commerce,Cuiyang 551400,Guizhou,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025 [2]贵州工商职业学院护理学院,贵州贵阳551400

出　　处：《中华中医药学刊》2019年第11期2708-2711,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81660762,81460694);贵州省科技计划项目(黔科合基础[2017]1401);贵州省教育厅创新群体重大研究项目(黔教合KY字[2017]041);贵州省教育厅项目(黔教合KY[2016]013);贵阳中医学院博士启动基金项目(贵中医博士启动[2017]02)

摘　　要：维生素D属人体内必需的脂溶性维生素,大多通过进食或照射阳光后获得,与肝、肾、甲状腺系统密切相关。维生素D不仅能改善骨骼系统疾病,还对结直肠癌等危重疾病有着正向调节作用。基于课题组前期研究发现,中医"肾精"与维生素D轴在获取来源、调控机制及治疗效用等方面存在密切的相关性且补肾疗法对于改善结直肠癌术后预后有着较好的疗效。据此推测,中医补肾疗法可能是通过调节维生素D轴治疗结直肠癌,维生素D轴可能是补肾治疗结直肠癌的潜在靶点。Vitamin D is an essential fat-soluble vitamin in the human body. It is obtained mostly by taking food or irradiating sunlight. It is closely related to the liver, kidney and thyroid system. Vitamin D not only improves the skeletal system diseases, but also has a positive regulatory effect on critical diseases such as colorectal cancer. Based on the previous study of our research group, we found that there is a close correlation between kidney essence and vitamin D axis in the source of acquisition, regulation mechanism and therapeutic efficacy, and kidney-tonifying therapy has a good effect on improving the prognosis of colorectal cancer after operation. It is speculated that the kidney-tonifying therapy of TCM may be the treatment of colorectal cancer by regulating the vitamin D axis, and vitamin D axis may be the potential target of kidney-tonifying therapy for colorectal cancer.

关 键 词：维生素D轴 补肾 结直肠癌 潜在靶点 探讨 

分 类 号：R735.37[医药卫生—肿瘤]