高危型人乳头瘤病毒感染与细菌性阴道病相关性分析  

Correlation between high-risk HPV infection and bacterial vaginosis in gynecological outpatient department

作　　者：谢美群[1] Xie Meiqun(Department of Gynecology Clinic,Jiaxing Maternal and Child Health Care Center,Jiaxing,Zhejiang 314000,China)

机构地区：[1]嘉兴市妇幼保健院妇科门诊,浙江省314000

出　　处：《中国基层医药》2019年第23期2899-2902,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨妇科门诊高危型人乳头瘤病毒(HPV)感染与细菌性阴道病的相关性.方法选择2017年1-6月在嘉兴市妇幼保健院妇科门诊就诊且同时进行阴道微生态检查以及HPV检查的患者1 563例,分析不同年龄患者高危型HPV感染率;并将1 563例患者分为高危型HPV阳性组和阴性组,分析两组女性阴道微生态相关指标及细菌性阴道病发生情况.结果 1 563例患者中,检出高危型HPV阳性患者385例,检出阳性率为24.63%,且随着年龄的增大,高危型HPV感染阳性率随之升高.高危型HPV阳性组与阴性组比较,pH 值 >4.5、过氧化氢以及白细胞酯酶阳性率差异无统计学意义(40.52%比59.48%,59.74%比40.26%,51.17%比48.83%)(χ^2 =1.625,0.188,3.610,均P>0.05),而唾液酸苷酶阳性率差异有统计学意义(12.47%比87.53%)(χ^2 =39.015,P<0.05).高危型HPV阳性组患者细菌性阴道病发生率及微生态四项指标均阳性率显著高于阴性组,差异有统计学意义(12.73%比6.03%,8.83%比3.65%)(χ^2 =18.377、16.629,均P<0.05).结论 高危型HPV感染与女性细菌性阴道炎密切相关,因此临床上需重视对细菌性阴道病的治疗,恢复阴道内微环境平衡,同时增强阴道以及宫颈免疫能力,以进一步降低高危型HPV感染.Objective To explore the correlation between high - risk human papillomavirus(HPV)infection and bacterial vaginosis in gynecological outpatient department.Methods From January 2017 to June 2017,1 563 cases of gynecologic outpatient who underwent vaginal microecological examination and HPV examination in Jiaxing Maternal and Child Health Care Center were selected to analyze the infection rate of high -risk HPV in different age groups.The 1 563 patients were divided into high-risk HPV positive group and negative group.The vaginal microecological indicators and the incidence of bacterial vaginosis in the two groups were analyzed.Results Among the 1 563 patients,385 caes were positive for high-risk HPV,the positive rate was 24.63%.The positive rate of high-risk HPV infection increased with age.There wereno statistically significant differences in pH > 4.5,hydrogen peroxide and leukocyte esterase positive rate between high -risk HPV positive group and negative group(40.52%vs.59.48%,59.74%vs.40.26%,51.17%vs.48.83%)(χ^2 =1.625,0.188,3.61,all P>0.05),but there was statistically significant difference in sialidase positive rate(12.47%vs.87.53%)(χ^2 =39.015,P <0.05).The incidence rate of bacterial vaginosis and the positive rate of microecology in the high-risk HPV positive group were significantly higher than those in the negative group(12.73%vs.6.03%,8.83%vs.3.65%)(χ^2 =18.377,16.629,all P <0.05).Conclusion High - risk HPV infection is closely related to female bacterial vaginitis,so it is necessary to pay more attention to the treatment of bacterial vaginosis,restore the balance of vaginal microenvironment,and enhance the vaginal and cervical immunity to further reduce high-risk HPV infection.

关 键 词：人乳头瘤病毒 阴道病 细菌性 高危 感染 微环境 

分 类 号：R73[医药卫生—肿瘤]