复方皂矾丸联合重组人粒细胞刺激因子注射液对血液肿瘤化疗后白细胞减少的影响  

Compound Zaofan Pills Combined with Recombinant Human Granulocyte-colony Stimulating Factor Injection Have Effect on Leukopenia after Chemotherapy for Hematological Tumor

作　　者：朱艳[1] 罗信国[1] 蒋志勇[1] 匡跃敏 黄黎[1] ZHU Yan;LUO Xinguo;JIANG Zhiyong;KUANG Yuemin;HUANG Li

机构地区：[1]金华市人民医院血液科

出　　处：《新中医》2019年第12期193-196,共4页New Chinese Medicine

摘　　要：目的:观察应用复方皂矶丸联合重组人粒细胞刺激因子注射液对血液肿瘤化疗后白细胞减少的临床疗效,评估其对患者症状及相关炎性因子的影响。方法:选择在本院化疗的血液肿瘤患者120例,均出现白细胞减少症,随机分为对照组及观察组各60例,对照组应用重组人粒细胞刺激因子注射液进行治疗,观察组同时给予复方皂矾丸。评估2组患者中医证候、临床疗效,分别检测患者白细胞计数、中性粒细胞计数、C-反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)水平,观察不良反应情况。结果:观察组白细胞减少改善临床总有效率为81.67%,高于对照组65.00%,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分、白细胞计数和中性粒细胞计数结果分别与治疗前比较,差异均有统计学意义(P<0.05)。治疗后,观察组中医证候积分低于对照组,差异有统计学意义(P<0.05);观察组白细胞计数及中性粒细胞计数均高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组CRP和TNF-α结果分别与治疗前比较,差异均有统计学意义(P<0.05)。治疗后,观察组CRP和TNF-α均低于对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:应用复方皂矾丸联合重组人粒细胞刺激因子注射液治疗血液肿瘤化疗后白细胞减少患者,能改善患者的临床症状,提高白细胞数量,降低炎性因子水平,并具有较好的安全性。Objective:To observe the clinical effect of compound Zaofan pills combined with recombinant human granulocyte-colony stimulating factor injection for leukopenia after chemotherapy for hematological tumor,and evaluate its effect on symptoms and relevant inflammatory factors of patients.Methods:Selected 120 cases of patients with hematological tumor who underwent chemotherapy in our hospital with the onset of leukopenia,and divided them into the control group and the observation group randomly,60 cases in each group.The control group received recombinant human granulocyte-colony stimulating factor injection,while the observation group additionally received compound Zaofan pills.Evaluated Chinese medicine syndrome and clinical effect of patients in both groups,respectively detected white blood cell count,neutrophil count and levels of C-creative protein(CRP)and tumor necrosis factor-a(TNF-a),and observed adverse reactions.Results:The total effective rate of leukopenia was 81.67%in the observation group,being higher than 65.00%in the control group,difference being significant(P<0.05).After treatment,comparing Chinese medicine syndrome scores,white blood cell count and neutrophil count in both groups with those before treatment,there were significant differences being found(P<0.05).After treatment,Chinese medicine syndrome scores in the observation group were lower than those in the control group,difference being significant(P<0.05);white blood cell count and neutrophil count in the observation group were respectively higher than those in the control group,differences being significant(P<0.05).After treatment,comparing the levels of CRP and TNF-a in both groups with those before treatment,there were significant differences being found(P<0.05).After treatment,the levels of CRP and TNF-a in the observation group were lower than those in the control group,differences being significant(P<0.05).Comparing the incidence of adverse reactions in both groups,there was no significant difference being found(P>0.05).Conclusion:The

关 键 词：白细胞减少 血液肿瘤 化疗 复方皂矾丸 重组人粒细胞刺激因子注射液 中性粒细胞计数 C-反应蛋白(CRP) 肿瘤坏死因子-α(TNF-α) 

分 类 号：R733[医药卫生—肿瘤] R557.1[医药卫生—临床医学]