Reactive uveitis, retinal vasculitis and scleritis as ocular end-stage of Acanthamoeba keratitis: a histological study  

作　　者：Lei Shi Tobias Hager Fabian Norbert Fries Loay Daas Leonard Holbach Carmen Hofmann-Rummelt Elena Zemova Berthold Seitz Nóra Szentmáry 

机构地区：[1]Department of Ophthalmology,Saarland University Medical Center,Homburg/Saar 66424,Germany [2]Department of Ophthalmology,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,Anhui Province,PR.China [3]Department of Ophthalm ology,Friedrich-A lexander University Erlangen-Niimberg,Erlangen 91052,Germany [4]Department of Ophthalmology,Semmelweis University,Budapest 1093,Hungary

出　　处：《International Journal of Ophthalmology(English edition)》2019年第12期1966-1971,共6页国际眼科杂志（英文版）

摘　　要：We analysed histologically two Acanthamoeba keratitis(AK) eyes with anterior and posterior segment inflammation and blindness. Two enucleated eyes of 2 patients(age 45 and 51y) with AK(PCR of epithelial abrasion positive) were analysed. Histological analysis was performed using hematoxylin-eosin, periodic acid-Schiff and G?m?rimethenamine silver staining. We could not observe Acanthamoeba trophozoites or cysts neither in the cornea nor in other ocular tissues. Meanwhile, we found uveitis, retinal vasculitis and scleritis in these eyes, due to the long-standing, recalcitrant AK. So in this stage of AK, systemic immune suppression may be necessary for a longer time period.● We analysed histologically two Acanthamoeba keratitis(AK) eyes with anterior and posterior segment inflammation and blindness. Two enucleated eyes of 2 patients(age 45 and 51y) with AK(PCR of epithelial abrasion positive) were analysed. Histological analysis was performed using hematoxylin-eosin, periodic acid-Schiff and G?m?rimethenamine silver staining. We could not observe Acanthamoeba trophozoites or cysts neither in the cornea nor in other ocular tissues. Meanwhile, we found uveitis, retinal vasculitis and scleritis in these eyes, due to the long-standing, recalcitrant AK. So in this stage of AK, systemic immune suppression may be necessary for a longer time period.

关 键 词：Acanthamoeba keratitis ENUCLEATION UVEITIS retinal vasculitis SCLERITIS 

分 类 号：R73[医药卫生—肿瘤]