地塞米松联合垂体后叶素预防产后出血的效果及对RhoA、ROCK蛋白影响  

Clinical outcomes of dexamethasone combined with pituitrin for treating women with postpartum hemorrhage and its influence on RhoA and ROCK proteins levels

作　　者：贾贝丽[1] 张念彩 杨冬梅[1] JIA Beili;ZHANG Niancai;YANG Dongmei(Qingdao Municipal Hospital,Shandong Province,266011)

机构地区：[1]青岛市市立医院

出　　处：《中国计划生育学杂志》2019年第12期1632-1635,共4页Chinese Journal of Family Planning

摘　　要：目的:分析地塞米松联合垂体后叶素预防产后出血效果及对RhoA、Rho相关卷曲螺旋形成蛋白激酶(ROCK)的影响。方法:选择2017年6月-2018年12月本院分娩的88例高危妊娠产妇为研究对象,根据简单随机法分为对照组(n=46)和观察组(n=42)。对照组采用地塞米松,观察组在对照组基础上联合垂体后叶素,比较两组止血效果,干预前后RhoA、ROCKⅠ、ROCKⅡ蛋白、血压、心率和不良反应。结果:干预后观察组总有效率(97.6%)高于对照组(84.8%),产后2h(172.0±23.2ml)、产后24h出血量(255.1±31.2ml)、产后出血率(2.4%)均低于对照组(287.3±38.7ml、340.2±45.3ml、15.2%),产后24h血红蛋白(121.1±16.0 g/L)高于对照组(113.1±13.3 g/L),RhoA(0.59±0.07 ng/ml)、ROCKⅠ(0.40±0.06 ng/ml)、ROCKⅡ(0.38±0.05 ng/ml)蛋白高于对照组(P<0.05);两组舒张压、收缩压、心率和不良反应发生无差异(P>0.05)。结论:地塞米松联合垂体后叶素可加强子宫收缩,调节RhoA、ROCK蛋白表达,预防宫缩乏力所致的产后出血,且用药安全。Objective:To analyze the influence of dexamethasone combined with pituitrin for treating women with postpartum hemorrhage on the levels of RhoA and Rho associated coiled coil forming protein kinase(ROCK).Methods:88 high risk pregnant women were selected as the research objects,and they were divided into control group(n=46)and research group(n=42)from June 2017 to December 2018 according to simple random method.The women in the control group were treated by dexamethasone,and the women in the research group were treated by dexamethasone combined with pituitrin.The hemostatic efficacy,postpartum bleeding volume,levels of RhoA,ROCKⅠ,and ROCKⅡprotein,blood pressure value,and heart rate before and after treatment,and adverse reactions rate of women were compared between groups.Results:The total effective rate and level of hemoglobin of women in the research group were 97.6% and 121.1±16.0 g/L,which were signifficent higher than those(84.8%and 113.1±13.3 g/L)of women in the control group(P<0.05).Volume of 2 h and 24 h postpartum blood loss,and postpartum bleeding rate of women in the research group were 172.0±23.2 ml,255.1±31.2 ml,and 2.4%,which were signifficent lower than those(287.3±38.7 ml,340.2±45.3 ml,and 15.2%)of women in the control group(P<0.05).The protein levels of RhoA,ROCKⅠ,and ROCKⅡof women in the research group were 0.59±0.07 ng/ml,0.40±0.06 ng/ml,and 0.38±0.05 ng/ml,which were signifficent higher than those of women in the control group(P<0.05).There were no significant different in the values of diastolic and systolic blood pressure,heart rate,and adverse reactions rate of women between the two groups(P>0.05).Conclusion:Dexamethasone combined with pituitrin can enhance uterine contraction,regulate RhoA and ROCK protein expression,prevent postpartum hemorrhage caused by uterine contraction,and has good safty.

关 键 词：产后出血 预防 地塞米松 垂体后叶素 RHOA蛋白 Rho相关卷曲螺旋形成蛋白激酶 

分 类 号：R73[医药卫生—肿瘤]