子宫肌瘤术后抗生素不同用药方案的效果及对血清炎症因子水平影响  

Effect of antibiotics used in different treatment regimens after hysteromyomectomy and its influence on serum inflammatory factors

作　　者：宋丽华[1] 史颖 邱育红[1] 茹亚 师晓艳[2] SONG Lihua;SHI Ying;QIU Yuhong;RU Ya;SHI Xiaoyan(The Second Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi Province,712000;Affiliated Hospital of Yan'an University)

机构地区：[1]陕西中医药大学第二附属医院,咸阳712000 [2]延安大学附属医院

出　　处：《中国计划生育学杂志》2019年第12期1675-1678,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨抗生素不同疗程及时机使用对子宫肌瘤术患者血清炎症因子水平及不良反应影响。方法:收集2018年6月30日-2019年3月30日本院子宫肌瘤剔除术患者120例临床资料,根据抗生素的使用时机和疗程分为4组各30例,A组术前1h静脉注射抗菌药,B组术前1h+术后6h静脉注射抗菌药,C组术前1h+术后连续3d(2次/d)静脉注射抗菌药,D组术后连续3d(2次/d)静脉注射抗生素。观察各组情况。结果:D组术后住院时间及住院费用均高于另外3组(P均<0.05)。各组甲级愈合、乙级愈合率无差异(P>0.05)。D组最高体温及术后24h、48h白细胞水平均高于另外3组,总感染发生率D组(43.3%)、A组(26.7%)高于B组(6.7%)、C组(6.7%)(P<0.05)。术后D组CRP、TNF-α、IFN-γ、IL-6水平高于另外3组(P<0.05)。总不良反应发生率C组、D组高于A组、B组(P<0.05)。结论:术前联合术后短疗程抗菌治疗效果及安全性最佳。Objective:To investigate the influence of antibiotics used in different courses of treatment and timing of administration on the levels of blood inflammatory factors and adverse reactions of women with uterine fibroids.Methods:The clinical data of 120 women with uterine fibroids who had experienced hysteromyomectomy from June 30,2018 to March 30,2019 were collected.According to the timing and course of antibiotics used,the included women were divided into 4 groups(30 cases in each group).The women in group A were given intravenous antibiotics 1 h before operation,the women in group B were given intravenous antibiotics 1 h before operation and 6 h after operation,the women in group C were given intravenous antibiotics 1 h before operation and 3 d after operation(2 times/d),and the women in group D were given intravenous antibiotics after 3 days(2 times/d).Results:The postoperative hospital stay,hospitalization expenses,the body temperature,blood cell level at 24 and 48 hours after operation,and the levels of CRP,TNF-α,IFN-γand IL-6 of women in group D were highest(P<0.05).There was no significant different in rates of grade A healing and grade B healing of women between the groups(P>0.05).The incidence of total infection of women in group D and group A was significant higher than that of women in group B and C(P<0.05).The incidence of total adverse reaction of women in group C and D was significant higher than that of women in group A and group B(P<0.05).Conclusion:The antibacterial therapy in short course for treating women before and after hysteromyomectomy has the best effect and safety.

关 键 词：子宫肌瘤剔除术 抗生素 使用时机 使用疗程 炎症因子 不良反应 

分 类 号：R73[医药卫生—肿瘤]