血清生化标志物联合超声用于唐氏综合征产前筛查的价值  

Value of serum biochemical markers combined with ultrasound for prenatal screening fetal Down syndrome

作　　者：周平安[1] 石秀英[1] 刁杰[1] 张小斌[1] 闫娟[1] ZHOU Pingan;SHI Xiuying;DIAO Jie;ZHANG Xiaobin;YAN Juan(Affiliated Hospital of Yan'an University,Yan'an,Shaanxi Province,716000)

机构地区：[1]延安大学附属医院

出　　处：《中国计划生育学杂志》2019年第12期1682-1685,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨血清生化标志物联合超声对唐氏综合征(DS)产前筛查的价值。方法:收集2017年1月-2019年6月本院筛查DS孕早期孕妇资料4001例,均行血清生化标志物联合超声检查。结果:4001例临床确诊6例DS,DS组孕妇血清游离人绒毛膜促性腺激素β(β-hCG)水平及胎儿颈项透明层(NT)厚度高于非DS组,血清妊娠相关血浆蛋白A(PAPP-A)水平低于非DS组(均P<0.05)。血清生化标志物筛查DS的灵敏度66.7%,特异度为99.6%,符合率99.6%;超声筛查DS的灵敏度为83.3%,特异度为99.6%,符合率99.5%;二者联合筛查DS的灵敏度为83.3%,特异度为99.9%,符合率为99.8%,特异度和符合率高于单独方法筛查(P<0.05)。结论:血清生化标志物及超声检查均为孕早期DS筛查的重要手段,二者联合应用更有利于DS的筛查。Objective:To explore the value of serum biochemical markers combined with ultrasound for prenatal screening fetal Down syndrome(DS).Methods:The data of 4001 pregnant women from January 2017 to June 2019 were collected,and all these included women were examined by serum biochemical markers combined with ultrasound for prenatal screening fetal DS.Results:6 fetuses of women in these 4001 pregnant women had been clinically diagnosed DS during the first tremister pregnancy.The serum levels of free human chorionic gonadotropinβ(freeβ-hCG)and fetal nuchal translucec(NT)value by ultrasound of women with DS fetus were significant higher than those of women without DS fetus,but the serum pregnancy-related plasma protein A(PAPP-A)level of women with DS fetus was significant lower(P<0.05).The sensitivity,specificity and coincidence rate of serum biochemical markers levels for screening DS were 66.7%,99.6%and 99.6%,respectively.The sensitivity,specificity,and coincidence rate of ultrasonic for screening DS were 83.3%,99.6%and 99.5%,respectively.The sensitivity,specificity and coincidence rate of serum biochemical markers levels combined with ultrasonic for screening DS were 83.3%,99.9%,and 99.8%,respectively.The specificity and coincidence rate of serum biochemical markers levels combined with ultrasonic for screening DS were signifficant higher than those of serum biochemical markers levels or ultrasound for screening DS alone(P<0.05).Conclusion:Serum biochemical markers levels and ultrasound are both important methods for screening DS during the first tremister pregnancy,but the combination screening can improve the efficacy of screening DS.

关 键 词：唐氏综合征 游离人绒毛膜促性腺激素β 妊娠相关血浆蛋白A 胎儿颈项透明层 筛查 血清学 超声 

分 类 号：R71[医药卫生—妇产科学]