Total triterpenes from fruits of Chaenomeles speciosa(Sweet) Nakai protect against indomethacin-induced gastric mucosal injury: involvement of TFF1-mediated EGF/EGFR and apoptotic pathways  

作　　者：FENG Min-lu LI Xiao-mei HE Hai-bo XU Hai-yan HE Yu-min ZHANG Yuan-yuan JIANG Wei-jie WANG Jun-zhi ZOU Kun 

机构地区：[1]Hubei Key Laboratory of Natural Products Research and Development,College of Biological and Pharmaceutical Sciences,China Three Gorges University,Yichang 443002,China [2]College of Medical Sciences,China Three Gorges University,Yichang 443002,China

出　　处：《中国药理学与毒理学杂志》2019年第9期683-684,共2页Chinese Journal of Pharmacology and Toxicology

基　　金：Research Foundation of Hubei Biological Enzyme Engineering Technology Research Center(JS2018-06)

摘　　要：OBJECTIVE Gastric ulcers affect people of all ages and half of the world's population,which is being considered as the new"plague of the 21st century".As is well known,gastric mucosa is known as the first guard to protect the stomach from ulcer injury,while the aetiology of gastric ulcer is relative to imbalances between gastric mucosal protective and aggressive factors.Therefore,reducing or eliminating the aggressive factors,returning to the balance of between mucosal protective and aggressive factors,and then restoring the normal functional of gastric mucosal barrier could be crucial for treating the gastric ulcer.The fruits of Chaenomeles speciosa(TCS),also known as"mugua",might be processed into edible and health care derived products,and used as a commonly used traditional medicine in China for thousands of years.In China folk,there is a saying that"apricot one benefit,pear two benefits,mgua hundred benefits",so it has a"hundred-benefit"fruit reputation.Tujia nationality inhabitants in Southwestern China should have rheumatic diseases and peptic ulcers for living in the damp environments and bingeing on spicy and pungent foods.For the exis⁃tence of the fruit derived products of Chaenomeles speciosa as their complementary foods or snacks,the habit makes them rarely suffer from the two kinds of diseases.Enlightened by these,we had investigated the structure-activity rela⁃tionships,screened out CSTT with gastroprotective activity.Our previous studies demonstrated that TCS owned effec⁃tively therapeutic effects on gastric ulcer patients and animals,and further confirmed that TFF1 and apoptotic pathway were closely interrelated with its exerting gastroprotection.However,its underlying molecular mechanisms involved have not been fully elucidated.The current study was to further investigate its protective effect on indomethacin(IND)-damaged RGM-1 cells and rats and its underlying mechanisms through modulating TFF1-mediated EGF/EGFR and apoptotic pathways.METHODS The gastroprotection of TCS was evaluated with OBJECTIVE Gastric ulcers affect people of all ages and half of the world’s population, which is being considered as the new "plague of the 21 stcentury". As is well known, gastric mucosa is known as the first guard to protect the stomach from ulcer injury, while the aetiology of gastric ulcer is relative to imbalances between gastric mucosal protective and aggressive factors. Therefore, reducing or eliminating the aggressive factors, returning to the balance of between mucosal protective and aggressive factors, and then restoring the normal functional of gastric mucosal barrier could be crucial for treating the gastric ulcer. The fruits of Chaenomeles speciosa(TCS), also known as "mugua", might be processed into edible and health care derived products, and used as a commonly used traditional medicine in China for thousands of years. In China folk, there is a saying that "apricot one benefit, pear two benefits, mgua hundred benefits",so it has a "hundred-benefit" fruit reputation. Tujia nationality inhabitants in Southwestern China should have rheumatic diseases and peptic ulcers for living in the damp environments and bingeing on spicy and pungent foods. For the existence of the fruit derived products of Chaenomeles speciosa as their complementary foods or snacks, the habit makes them rarely suffer from the two kinds of diseases. Enlightened by these, we had investigated the structure-activity relationships, screened out CSTT with gastroprotective activity. Our previous studies demonstrated that TCS owned effectively therapeutic effects on gastric ulcer patients and animals, and further confirmed that TFF1 and apoptotic pathway were closely interrelated with its exerting gastroprotection. However, its underlying molecular mechanisms involved have not been fully elucidated. The current study was to further investigate its protective effect on indomethacin(IND)-damaged RGM-1 cells and rats and its underlying mechanisms through modulating TFF1-mediated EGF/EGFR and apoptotic pathways. METHODS The gastroprotection

关 键 词：fruits of Chaenomeles speciose total triterpenoids GASTROPROTECTION gastric mucosal injury 

分 类 号：R73[医药卫生—肿瘤]