Protective effect of active ingredient of Ferula sinkiangensis on global cerebral ischemia-reperfusion mice  

作　　者：ZHANG Wen-qiang MI Yan XU Ji-kai LI Ning HOU Yue 

机构地区：[1]College of Life and Health Sciences,Northeastern University,Shenyang 110169,China [2]Key Laboratory of Data Analytics and Optimization for Smart Industry,Northeastern University,Ministry of Education,Shenyang 110169,China [3]School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China

出　　处：《中国药理学与毒理学杂志》2019年第9期735-735,共1页Chinese Journal of Pharmacology and Toxicology

基　　金：National Natural Science Foundation of China(U1603125;81473330;81872768;81673323);Fundamental Research Funds for the Central Universities of China(N182008004;N182006001);Liaoning Revitalization Talents Program(XLYC1807118);Liaoning BaiQianWan Talents Program(2018)

摘　　要：OBJECTIVE Learning and memory impairment is one of the common sequelae of stroke patients,which is called"post-stroke dementia"and seriously affects the quality of life of the patients.For post-stroke dementia,there is still no effective clinical treatment.In the present study,we aim to investigate the effect of the active ingredient of Ferula sinkiangensis,AW09,on global cerebral ischemia-reperfusion mice.METHODS The bilateral common carotid artery occlusion(BCCAO)reperfusion model was used to investigate the protective effect of AW09 on cognitive dysfunction in mice with global cerebral ischemia reperfusion.Y-maze and Morris water maze were used to test the learning and memory ability of mice.RESULTS Y-maze test showed that AW09 treatment significantly increased the spontaneous alternation rate of BCCAO model animals and had no significant effect on the total number of arm entries.The results of Morris water maze showed that AW09 significantly reduced the escape latency of BCCAO mice during the training period.During the probe test phase,AW09 significantly increased the swimming time in target quadrant,distance in target quadrant and number of platform crossings and decreased the swimming time in the quadrant opposite the target quadrant of BCCAO mice.CONCLUSION AW09,the active ingredient of Ferula sinkiangensis,can improve working memory impairment and spatial memory impairment in animals with global cerebral ischemia-reperfusion,suggesting that AW09 has poten⁃tial therapeutic value for cognitive dysfunction caused by global cerebral ischemia.OBJECTIVE Learning and memory impairment is one of the common sequelae of stroke patients, which is called "post-stroke dementia" and seriously affects the quality of life of the patients. For post-stroke dementia, there is still no effective clinical treatment. In the present study, we aim to investigate the effect of the active ingredient of Ferula sinkiangensis, AW09, on global cerebral ischemia-reperfusion mice. METHODS The bilateral common carotid artery occlusion(BCCAO) reperfusion model was used to investigate the protective effect of AW09 on cognitive dysfunction in mice with global cerebral ischemia reperfusion. Y-maze and Morris water maze were used to test the learning and memory ability of mice. RESULTS Y-maze test showed that AW09 treatment significantly increased the spontaneous alternation rate of BCCAO model animals and had no significant effect on the total number of arm entries. The results of Morris water maze showed that AW09 significantly reduced the escape latency of BCCAO mice during the training period. During the probe test phase, AW09 significantly increased the swimming time in target quadrant, distance in target quadrant and number of platform crossings and decreased the swimming time in the quadrant opposite the target quadrant of BCCAO mice. CONCLUSION AW09, the active ingredient of Ferula sinkiangensis, can improve working memory impairment and spatial memory impairment in animals with global cerebral ischemia-reperfusion, suggesting that AW09 has potential therapeutic value for cognitive dysfunction caused by global cerebral ischemia.

关 键 词：Ferula sinkiangensis ISCHEMIA-REPERFUSION learning and memory. 

分 类 号：R74[医药卫生—神经病学与精神病学]