不同剂量双柏散外敷对脾心痛(急性轻型胰腺炎)疗效的影响  

Influence of Curative Effect of Splenic Precordial Pain (Acute Mild Pancreatitis) by Different Doses of Shuangbai Powder by External Application

作　　者：王永亮 翟淑萍 王百林[2] 苑伟 张北平 章小兵 贾伟路 袁辉 WANG Yongliang;ZHAI Shuping;WANG Bailin;YUAN Wei;ZHANG Beiping;ZHANG Xiaobing;JIA Weilu;YUAN Hui(Guizhou Medical University,Guiyang 550004,Guizhou,China;General Surgery of Guangzhou Red Cross Hospital Affiliated to School of Medicine of Jinan University,Guangzhou 510220,Guangdong,China)

机构地区：[1]贵州医科大学,贵州贵阳550004 [2]广州市红十字会医院普外科,暨南大学医学院附属广州红十字会医院,广州510220

出　　处：《辽宁中医杂志》2019年第11期2368-2370,I0001,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：广东省中医药管理局资助项目(20171206)

摘　　要：目的:观察双柏散外敷辅助治疗脾心痛(急性轻型胰腺炎)的临床疗效,筛选较合适的治疗剂量参数。方法:本研究将符合方案分析集分析(PPS)的60例急性轻型胰腺炎患者随机分为双柏散组(双柏散外敷+西医基础治疗)及对照组(西医基础治疗),再将双柏散组按剂量分为3个亚组(50 g、100 g、200 g)。对比各组的腹痛缓解、腹部压痛消失、肛门排气以及血淀粉酶恢复正常等所需的时间指标。结果:(1)生存分析的检验结果显示双柏散组与对照组在腹痛缓解、腹部压痛消失、肛门排气以及血淀粉酶恢复正常等所需的时间指标上均有显著差异,差异有统计学意义(P<0.05)。(2)各组间疗效指标的关系:①在以上指标中50 g双柏散组与对照组相比均无明显差异(P>0.05);②100 g与200 g双柏散组的临床疗效明显优与对照组,各项指标差异显著,差异均具有统计学意义(P<0.05),但两亚组各指标之间的差异均无统计学意义(P>0.05)。结论:研究结果表明双柏散外敷治疗脾心痛(急性轻型胰腺炎)的临床疗效确切,其剂量与疗效不完全呈正相关性,双柏散100 g是较适宜的治疗方案。Objective:To observe the clinical efficacy of different doses of Shuangbai Powder by external application as an assistant treatment for the patients with splenic precordial pain(acute mild pancreatitis)and select the most proper therapeutic dose.Methods:This research divided 60 patients with acute pancreatitis into the Shuangbai Powder group 30 cases and the control group30 cases,which were analyzed by per-protocol population set(PPS).Shuangbai Powder group was further divided into 3 subgroups by the different doses(50 g,100 g,200 g).We compared the difference of upper quadrant pain relief time,abdominal tenderness disappearance,flatus emission and blood amylase normalizationamong the groups.Results:(1)The survival analysis of the test results indicated that the clinical efficacy difference between the control group and the treatment group had statistical significance(P<0.05).(2)The relationship between two groups’efficacy index:①Between control group and Shuangbai Powder group 1(50 g),the above indexes had no statistical significance(P>0.05).②The above efficacy index of Shuangbai Powder Group 2(100 g),Shuangbai Powder Group 3(200 g)wassuperior tothat of the control group(P<0.05).However,there was no statistically significant difference between the two in the above indicators(P>0.05).Conclusion:The research showed that curative effect of splenic precordial pain(acute mild pancreatitis)by Shuangbai Powder was definite.However,the dose is not fully positively correlated with the curative effect,we recommend that 100 g is the most proper therapeutic dose.

关 键 词：中医外治 双柏散 脾心痛 疗效 剂量 

分 类 号：R576[医药卫生—消化系统]