碘伏稀释液肛周坐浴对恶性血液肿瘤化疗患者肛周感染的防控效果研究  

Effect of iodophor diluent perianal bath on the prevention and treatment of perianal infection in patients with malignant hematological malignancies undergoing chemotherapy

作　　者：卢玲 葛永芹[1] 朱霞明[1] 赵素芳[1] 毛燕琴[1] 陆茵[1] 吴德沛[1] LU Ling;GE Yong-qin;ZHU Xia-ming;ZHAO Su-fang;MAO Yan-qin;LU Yin;WU De-pei(First Hospital Affiliated to Suzhou University,Suzhou Jiangsu 215006,China)

机构地区：[1]苏州大学附属第一医院血液科

出　　处：《中华医院感染学杂志》2019年第22期3453-3456,3493,共5页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(81730003)

摘　　要：目的探索碘伏稀释液肛周坐浴对恶性血液肿瘤化疗患者肛周感染的防控效果。方法选取2015年6月-2018年6月于苏州大学附属第一医院接受治疗的124例恶性血液肿瘤患者为研究对象,按照随机数表法分为研究组和对照组,每组各62例,研究组应用碘伏稀释液肛周坐浴治疗方案,对照组应用常规高锰酸钾坐浴治疗方案。对治疗后两组患者发生肛周感染情况进行分析,根据患者感染情况及相关临床标准进行疗效评价,对患者治疗后发生的肛周脓肿、皮肤黏膜破损、肛周不适等并发症进行统计,并计算并发症总发生率。结果研究组治疗后共发现2例肛周感染,其中1例Ⅰ级感染,1例Ⅱ级感染;对照组治疗后共发现10例肛周感染,其中5例Ⅰ级感染,3例Ⅱ级感染,2例Ⅲ级感染;研究组肛周感染总发生率为3.23%低于对照组肛周感染总发生率16.13%(P=0.032)。研究组疗效优于对照组(P=0.032)。研究组治疗期间发现1例皮肤黏膜破损,2例肛周不适,对照组治疗期间发现1例肛周脓肿,4例皮肤黏膜破损,6例肛周不适;研究组治疗期间肛周并发症发生率为4.84%低于对照组17.74%(P=0.043)。结论碘伏稀释液肛周坐浴较常规高锰酸钾坐浴能有效减少恶性血液肿瘤化疗患者肛周感染的发生,且能减轻患者肛周感染的严重程度,同时碘伏稀释液肛周坐浴治疗肛周感染并发症发生较少,疗效显著,具有一定的临床意义。OBJECTIVE To explore the effect of iodophor diluent perianal bath on the prevention and control of perianal infection in patients with malignant hematological malignancies undergoing chemotherapy.METHODS A total of 124 patients with malignant hematologic malignancies who were treated in the First Affiliated Hospital of Soochow University from June 2015 to June 1818 were enrolled.Subjects were divided into the study group and the control group by using the random number tables,62 cases in each group.The study group was treated with iodophor dilute solution for anal sac bath,and the control group was treated with conventional potassium permanganate bath.The incidence of perianal infection between the two groups after the treatment was compared,and the efficacy was evaluated according to the patients’infection degree and relevant clinical criteria.The complications such as perianal abscess,skin mucosal damage and perianal discomfort after the treatment were recorded,and the total incidence of complications was calculated.RESULTS After the treatment,2 cases of perianal infection were found in the study group,including 1 case of grade I infection and 1 case of grade II infection.After the treatment,10 cases of perianal infection were found in the control group:5 cases of grade I infection,3 cases of grade II infection and 2 cases of grade III infection.The total incidence of perianal infection in the study group was 3.23%,which was significantly lower than that in the control group(16.13%)(P=0.032).The effect of the treatment in the study group was significantly better than that in the control group(P=0.032).One case of skin mucosal damage and 2 cases of perianal discomfort were found during the treatment in the study group;1 case of perianal abscess,4 cases of skin mucosal damage and 6 cases of perianal discomfort were found in the control group.The incidence of perianal complication in the study group was 4.84%,which was significantly lower than that in the control group(P=0.043).CONCLUSION Compared with conventio

关 键 词：碘伏稀释液 肛周坐浴 恶性血液肿瘤化疗 肛周感染 防控效果 

分 类 号：R73[医药卫生—肿瘤]