18F-FDG PET/CT代谢参数与子宫内膜癌相关临床病理特征的关系  

Relationship between metabolic parameters of 18F-FDG PET/CT and clinicopathological features related to endometrial carcinoma

作　　者：陈丹丹 楼云龙[1] 宋丽 陈文忠 章明 李铨 林炜 王全师[2] CHEN Dan-dan;LOU Yun-long;SONG Li;CHEN Wen-zhong;ZHANG Ming;LI Quan;LIN Wei;WANG Quan-shi(Department of Nuclear Medicine,Meizhou People’s Hospital,Meizhou Guangdong 514031,China;PET Center,Nanfang Hosptial,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]梅州市人民医院核医学科,广东梅州514031 [2]南方医科大学南方医院PET中心,广东广州510515

出　　处：《中国临床医学影像杂志》2019年第12期888-891,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:评价子宫内膜癌原发灶的代谢参数与患者临床病理特征的关系。方法:回顾性分析术前行18F-FDG PET/CT检查的78例子宫内膜癌患者的临床资料,以子宫内膜癌原发灶的最大标准摄取值(SUVmax)的40%作为阈值,在横断位、矢状位和冠状位上对病灶进行容积分割,得出原发灶的SUVmax、代谢体积(MTV)以及病灶糖酵解总量(TLG)。结果:78例子宫内膜癌原发灶的最大径、SUVmax、MTV和TLG分别为3.0 cm(1.5 cm,7.5 cm)、13.0(3.8,33.0)、9.0 cm3(1.5 cm3,56.0 cm3)和61.8 g(8.3 g,463.6 g)。不同组织学分级及子宫浸润深度的SUVmax、MTV和TLG差异均有统计学意义(均P<0.05),不同FIGO分期及有无淋巴结转移的MTV和TLG差异均有统计学意义(均P<0.05)。SUVmax、MTV和TLG与肿瘤最大径、子宫浸润深度及肿瘤组织分级均呈正相关(均P<0.05),MTV和TLG与FIGO分期、有无淋巴结转移均呈正相关(均P<0.05),且TLG与肿瘤最大径的相关系数最高。结论:18F-FDG PET/CT代谢参数尤其是TLG与子宫内膜癌的临床病理特征具有较好的相关性。Objective: To evaluate the relationship between metabolic parameters of primary endometrial carcinoma and clinicopathological characteristics of patients. Methods: A retrospective analysis of preoperative 18F-FDG PET/CT check of the clinical data of 78 examples patients with endometrial carcinoma, determined the 40% SUVmax of primary endometrial carcinoma as the threshold in transection, sagittal and coronal plane for volume segmentation of lesion. Then we measured the primary focal SUVmax, metabolic volume(MTV) and total lesions glycolysis(TLG). Results: The maximum diameter, SUVmax, MTV and TLG were 3.0 cm(1.5 cm, 7.5 cm), 13.0(3.8, 33.0), 9.0 cm3(1.5 cm3, 56.0 cm3) and 61.8 g(8.3 g, 463.6 g), respectively. SUVmax, MTV and TLG of different histological grades and uterine infiltration depth were statistically significant(P <0.05), and MTV and TLG of different FIGO stages and lymph node metastasis were statistically significant(P<0.05). SUVmax, MTV and TLG were positively correlated with tumor maximum diameter, uterine infiltration depth and tumor tissue grading(P<0.05), MTV and TLG were positively correlated with FIGO stage and lymph node metastasis(P<0.05), and TLG had the highest correlation coefficient with tumor maximum diameter. Conclusion:18F-FDG PET/CT metabolic parameters, especially TLG, have a good correlation with the clinicopathological features of endometrial carcinoma.

关 键 词：子宫内膜肿瘤 氟脱氧葡萄糖F18 正电子发射断层显像术 

分 类 号：R737.33[医药卫生—肿瘤] R817.4[医药卫生—临床医学]