CBCT对肺癌SBRT摆位误差及靶区外放边界的校正价值  

The setup error and the determination of target position based on cone beam CT for early non-small cell lung cancer by stereotactic body radiation therapy

作　　者：张惠玲[1] 许会军[1] 吴小良[1] 陈晓芳[1] 赵鹏[1] 张伟[1] 马志乾[1] 乞国艳[1] ZHANG Huiling;XU Huijun;WU Xiaoliang(The First Hospital of Shijiazhuang City, Hebei, Shijiazhuang 050011, China)

机构地区：[1]河北省石家庄市第一医院

出　　处：《河北医药》2019年第24期3777-3779,3783,共4页Hebei Medical Journal

基　　金：石家庄市科学技术研究与发展计划项目(编号:171462203)

摘　　要：目的通过锥形束CT(CBCT)图像配准确定早期非小细胞肺癌体部立体定向放射治疗(SBRT)的摆位误差探讨MPTV靶区勾画外扩范围,为临床提供参考数据。方法选取13例早期非小细胞肺癌患者,应用CBCT对患者进行治疗前扫描,并记录摆位误差。根据MPTV外扩公式(MPTV=2.5∑+0.7σ)得出靶区(PTV)的摆位误差范围。结果X平移=(0.16±0.14)cm、Y平移=(0.45±0.37)cm、Z平移=(0.21±0.21)cm;X旋转=(0.45±0.52)°、Y旋转=(1.26±1.39)°、Z旋转=(0.84±0.82)°。MPTV在X轴、Y轴、Z轴的外扩范围分别为0.51 cm、1.01 cm、0.58 cm。结论采用CBCT图像引导患者靶区位置校准,可准确得到非小细胞肺癌患者因摆位误差导致的PTV外扩边界,为临床靶区勾画范围提供参考依据。Objective To investigate the setup error and the determination of target position based on cone beam CT for early non-small cell lung cancer(NSCLC)by stereotactic body radiation therapy,and to explore the target margin of MPTV so as to provide reference data for clinical practice.Methods A total of 13 patients with early NSCLC were enrolled in the study.Before treatment,the patients underwent CBCT,and the setup error was recorded.According to the formula(MPTV=2.5∑+0.7σ),and the setup error range of PTV was got.Results The translational setup errors on X axis(left-right,LR),Y axis(superior-inferior,SI)and Z axis(anterior-posterior,AP)were(0.16±0.14)cm,(0.45±0.37)cm,(0.21±0.21)cm,respectively,and the rotational setup errors on X axis,Y axis,Z axis were(0.45±0.52)°,(1.26±1.39)°,(0.84±0.82)°,respectively.According to the formula,and the translational ranges of MPTV on X axis,Y axis,Z axis were 0.51cm,1.01cm,0.58cm,respectively.Conclusion The setup error coming from CBCT images can calculate the margin of PTV in patients with NSCLC accurately,which can provide reference data for clinical practice.

关 键 词：非小细胞肺癌 锥形束CT 摆位误差 外放边界 

分 类 号：R734.2[医药卫生—肿瘤]