维生素D及其类似物在口腔黏膜病与牙周病治疗中的作用  

The role of vitamin D and its analogues in the treatment of oral mucosal diseases and periodontal diseases

作　　者：吴倩[1] 王健[1] 牛丽 杨雪[1] 唐晓琳[1] WU Qian;WANG Jian;NIU Li;YANG Xue;TANG Xiaolin(Department of Periodontics,School of Stomatology,China Medical University,Shenyang 110002,China)

机构地区：[1]中国医科大学附属口腔医院牙周病科

出　　处：《口腔疾病防治》2019年第12期804-808,共5页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金项目（81670999）

摘　　要：维生素D是体内必不可少的营养物质,近年来,维生素D在调节免疫和抗炎方面的作用受到越来越多的关注。但是,维生素D在体内应用可能产生高钙血症、高钙尿症等副作用。因此,通过分子改建得到的维生素D类似物可以保留与维生素D相似的调节作用,同时降低副作用。补充维生素D或应用维生素D类似物可能有助于免疫炎症性疾病的预防和治疗。现围绕维生素D及其类似物在口腔黏膜病与牙周病防治中的作用做一综述。文献复习结果表明,维生素D及其类似物对口腔黏膜屏障的完整性起到保护作用,阻止或延缓口腔扁平苔藓的发生,也可为预防及治疗牙周炎提供参考价值。Vitamin D is an essential nutrient in the body.In recent years,increasing attention has been paid to its role in regulating immunity and anti⁃inflammatory effects.However,the application of vitamin D in vivo may produce some side effects,such as hypercalcemia and hypercalciuria.Some analogs of vitamin D obtained through molecular modification can reduce the side effects while retaining a similar regulatory action as that of vitamin D.The supplemen⁃tation of vitamin D or the use of vitamin D analogs may contribute to the prevention and treatment of immune inflamma⁃tory diseases.This article reviews the role of vitamin D and its analogues in the prevention and treatment of oral muco⁃sal diseases and periodontal diseases.The literature review results show that vitamin D and its analogues can protect the integrity of the oral mucosal barrier,prevent or delay the occurrence of oral lichen planus,and provide a reference value for the prevention and treatment of periodontitis.

关 键 词：维生素D 类似物 钙磷代谢 维生素D受体 高钙血症 高钙尿症 免疫 炎症 

分 类 号：R78[医药卫生—口腔医学]