胎盘多肽联合放射性粒子植入治疗口腔癌的疗效观察  

Therapeutic effect of placenta polypeptide combined with radioactive seed implantation on oral cancer

作　　者：任起辉[1] 司亚静[1] 刘婉仪 REN Qihui;SI Yajing;LIU Wanyi(Department of Dentistry,the First Affiliated Hospital of He’nan University of Science and Technology,Luoyang 471000,He’nan,China)

机构地区：[1]河南科技大学第一附属医院口腔科

出　　处：《癌症进展》2019年第23期2807-2810,2846,共5页Oncology Progress

摘　　要：目的探讨胎盘多肽联合放射性粒子植入治疗口腔癌的疗效。方法根据随机数字表法将200例口腔癌患者分为对照组(n=88)和研究组(n=112),对照组患者采用放射性粒子植入治疗,研究组患者采用胎盘多肽联合放射性粒子植入治疗。比较两组患者的近期疗效、治疗期间不良反应发生情况及治疗前后肿瘤标志物水平、免疫功能相关指标水平、功能状态,并对两组患者的1年生存情况进行比较。结果研究组患者的治疗总有效率高于对照组(P﹤0.05)。治疗前,两组患者的肿瘤标志物[癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、鳞状细胞癌抗原(SCCAg)及细胞角质蛋白19片段抗原21-1(CYFRA21-1)]水平、免疫功能相关指标水平[CD4+、CD8+、CD4+/CD8+、自然杀伤(NK)细胞]、卡氏功能状态(KPS)评分比较,差异均无统计学意义(P﹥0.05);治疗后,研究组患者的血清CEA、CA19-9、SCCAg、CYFRA21-1水平及CD8+水平均低于对照组,CD4+、CD4+/CD8+、NK细胞水平及KPS评分均高于对照组,差异均有统计学意义(P﹤0.05)。研究组患者腹泻、恶心呕吐、口腔黏膜炎、肝功能不全、脱发、外周神经毒性的发生率均低于对照组(P﹤0.05)。研究组患者的生存结局优于对照组(P﹤0.05)。结论胎盘多肽联合放射性粒子植入治疗口腔癌的疗效较好,且可以有效降低血清肿瘤标志物水平,改善机体的免疫功能,延长患者的生存时间,且放射性粒子植入相关不良反应发生率低。Objective To observe the efficacy of placenta polypeptide combined with radioactive seed implantation in the treatment of oral cancer.Method Two hundred patients with oral cancer were included and divided into control group(n=88)and study group(n=112)according to a random number table.Patients in control group were treated with radioactive seed implantation,while those in study group were administered with placenta polypeptide combined with radioactive seed implantation.The short-term efficacy,adverse reactions during treatment,levels of tumor marker before and after treatment,immune function parameters,Karnofsky functional status(KPS)score,as well as the 1-year survival were compared between the two groups.Result The overall response rate in study group was significantly higher than that in the control group(P<0.05).Before treatment,there were no significant differences regarding the level of tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),squamous cell carcinoma antigen(SCCAg),cytokeratin 19 fragment antigen 21-1(CYFRA21-1)]and immune function parameters[CD4+,CD8+,CD4+/CD8+,and nature killer(NK)cells],and KPS score between the two groups(P>0.05).After treatment,the levels of serum CEA,CA19-9,SCCAg,CYFRA21-1 and CD8+in study group were lower compared to control group,and levels of CD4+,CD4+/CD8+,and NK cells as well as KPS score were all higher than those in the control group,indicating statistically significant differences(P<0.05).Study group patients developed significantly less adverse reactions including diarrhea,nausea and vomiting,oral mucositis,liver dysfunction,alopecia,peripheral neurotoxicity as compared with control group(P<0.05).Better survival outcomes were observed in patients in the study group compared with control group(P<0.05).Conclusion Placenta polypeptide combined with radioactive seed implantation is clinically effective in the treatment of oral cancer,and the regimen may reduce the level of serum tumor markers,improve the immune function,and prolong survival t

关 键 词：口腔癌 胎盘多肽 放射性粒子植入 疗效 

分 类 号：R739.8[医药卫生—肿瘤]