急性高白细胞性白血病的临床研究进展  

Research progress of hyperleukocytic acute leukemia

作　　者：胡瑜 郑波 Hu Yu;Zheng Bo(Ningxia Medical University,Yinchuan 750004,Ningxia Hui Autonomous Region,China;Department of Hematology,General Hospital of Ningxia Medical University,Yinchuan 750004,Ningxia Hui Autonomous Region,China)

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学总医院血液科,银川750004

出　　处：《国际输血及血液学杂志》2019年第6期535-542,共8页International Journal of Blood Transfusion and Hematology

摘　　要：急性高白细胞性白血病(AHL)是指初发急性白血病患者的外周血白细胞计数(WBC)>100×109/L.外周血白细胞计数>100×10^9/L,亦被称为高白细胞血症(HL),常见于急性髓细胞白血病(AML)和急性淋巴细胞白血病(ALL).AHL临床起病急骤、进展迅速,导致该病患者的早期病死率高、预后差,并且因其白细胞淤滞症、肿瘤溶解综合征(TLS)、弥漫性血管性凝血(DIC)等并发症均可威胁患者生命,而需要紧急干预,故AHL被认为是血液科危急重症.如何降低AHL患者的早期死亡率,是目前相关临床研究的重点.笔者拟就AHL的流行病学、病理生理学、临床表现及目前治疗进展进行综述.Acute hyperleukocytic leukemia (AHL)refers to acute leukemia patients whose peripheral white blood cell count (WBC)is more than 100 × 10^9/L.It is called hyperleukocytosis (HL),when peripheral WBC is more than 100 × 109/L.It is common in acute myeloid leukemia (AML)and acute lymphoblastic leukemia (ALL).AHL has a rapid onset,rapid progress,high early mortality and poor prognosis,which is a critical disease in hematology department.Because of its complications such as leukostasis,tumor lysis syndrome (TLS),disseminated intravascular coagulation (DIC),patients'lives are threatened and need urgent intervention.Therefore,how to reduce the early mortality of patients with AHL is an important research topic.This article reviews the epidemiology, pathophysiology and clinical manifestations of AHL,especially the current treatment options.

关 键 词：白细胞增多 白血病 肿瘤溶解综合征 急性高白细胞性白血病 高白细胞血症 早期死亡率 流行病学研究 白细胞淤滞症 

分 类 号：R73[医药卫生—肿瘤]