子宫颈柯凝卡冷刀锥切术和传统冷刀锥切术在治疗子宫颈高级别病变的疗效研究  

Clinical ef?cacy of CoolingCut cold knife conization and traditional cold knife conization in the treatment of high grade cervical lesions

作　　者：赵超[1] 徐学春 张志军[3] 王丹 王建六[1] 魏丽惠[1] ZHAO Chao;XU Xuechun;ZH ANG Zhijun;WANG Don;WANG Jianliu;W EI Lihui(Department o f Obstetrics&Gynecology,Peking University People's Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院妇产科,100044 [2]新疆乌鲁木齐市友谊医院 [3]贵州省人民医院 [4]贵州六盘水市妇幼保健院

出　　处：《中国妇产科临床杂志》2019年第6期491-493,共3页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：国家科技支撑计划(2015BAI13B06)

摘　　要：目的比较宫颈柯凝卡冷刀锥切术和传统冷刀锥切术(cold knife conization,CKC)对于宫颈高级别病变的临床疗效。方法选取2017年6月至2018年6月就诊于北京大学人民医院、手术资料完整的宫颈高级别病变患者共302例,其中柯凝卡冷刀锥切组150例,传统冷刀锥切组152例。随访至2019年1月,比较两组患者年龄及手术前后病理分级并评估手术时间、术中出血量、病理切缘阳性率及术后复发等情况。结果两组患者年龄及手术前后病理分级比较,差异均无统计学意义(P>0.05)。柯凝卡冷刀锥切组术中平均出血量[(6.14±5.38)ml]与传统冷刀锥切组[(25.22±63.66)ml]比较,差异有统计学意义(P<0.05)。柯凝卡冷刀锥切组平均手术时间[(22.33±9.44)min]、病理切缘阳性率(12.67%)及术后复发率(0例)与传统冷刀组【分别为(29.93±11.78)min、11.18%及0例】比较,差异均无统计学意义(P>0.05)。结论两种冷刀锥切方法用于治疗宫颈高级别病变均准确有效。与传统冷刀锥切术相比,柯凝卡冷刀锥切术可明显减少患者的术中出血量。Objective To compare the clinical efficacy of CoolingCut cold knife conization and traditional cold knife conization in the treatment of cervical high grade lesions.Methods The clinical data of 150 patients with cervical high grade lesions underwent CoolingCut cold knife conization(CoolingCut CKC group)and 152 cases underwent traditional cold knife conization(traditional CKC group)in Peking University People's Hospital from Jun 2017 to Jun 2018 were collected.The patients'age,mean operative time,preoperative pathological grading,blood loss during the operation,positive resected margin and recurrence were compared between the two groups.Results There was no significant difference on the patients,age and preoperative pathological grading between the two groups(P>0.05).The mean blood loss during the operation[(6.14±5.38)ml]of CoolingCut CKC group was significantly different from those of Traditional CKC group[(25.22±63.66)ml](P<0.05).There was no statistical difference on the mean operation time,rate of positive margin and recurrence rate between Coolingcut CKC group(22.33±9.44 min,12.67%,0)and traditional CKC group[(29.93±11.78)min],(11.18%,0)respectively(P>0.05).Conclusions Both Coolingcut and traditional CKC are safe as well as effective in the treatment of high grade cervical lesions.Compared with traditional CKC,Coolingcut CKC has the advantage of less intraoperative blood loss.

关 键 词：宫颈冷刀锥切术 柯凝卡冷刀锥切术 宫颈高级别病变 治疗 

分 类 号：R73[医药卫生—肿瘤]