大气污染物对杭州市小学生唾液溶菌酶含量的影响  

Effect of air pollutants on salivary lysozyme of pupils in Hangzhou

作　　者：刘卫艳[1] 徐虹[1] 刘静[2] LIU Weiyan;XU Hong;LIU Jing(Hangzhou Center for Disease Control and Prevention,Hangzhou(310021),China)

机构地区：[1]浙江省杭州市疾病预防控制中心环境所,310021 [2]温州医科大学

出　　处：《中国学校卫生》2019年第11期1712-1714,共3页Chinese Journal of School Health

基　　金：浙江省医药卫生科技计划项目(2015KYB317);杭州市科技发展计划项目(20140533B15)

摘　　要：目的研究杭州市大气污染物对小学生唾液溶菌酶含量的影响,为有效改善小学生健康指标提供参考。方法2015年10月至2016年3月,随机整群抽取杭州市下城区、西湖区、淳安县3所学校共248名小学生采集唾液样品,收集同期3所学校附近的环境空气质量和气象资料,利用混合线性模型分析大气污染物对小学生唾液溶菌酶含量的影响。结果西湖区、下城区2次测量唾液酶含量差异有统计学意义(t值分别为-4.49,2.75,P值均<0.01)。不同性别、年龄小学生唾液溶菌酶含量差异无统计学意义。混合线性模型提示,测试当天的PM2.5,PM10,SO2,NO2,CO浓度每升高1μg/m3,唾液溶菌酶分别升高1.75,0.82,6.12,1.05,70.73μg/L;测试前1天SO2的质量体积浓度每升高1μg/m3,唾液溶菌酶升高8.17μg/L。结论小学生唾液溶菌酶水平与接触大气污染物的质量体积浓度存在正相关,且有滞后效应。Objective To explore the effect of air pollutants on salivary lysozyme of pupils in Hangzhou,and to provide a reference for effectively improving health index of primary school students. Methods A total of 248 healthy pupils from one primary school in Xiacheng district, Xihu district and Chun’an county of Hangzhou were selected with cluster random sampling methods during October 2015 to March 2016. Meteorological and air quality data near the three schools during the same period were collected. Mixed linear model was used to analyze the influence of air pollutants on salivary lysozyme of pupils. Results There was significant difference in the content of salivary enzymes between Xihu District and Xiacheng District(t=-4.49, 2.75, P<0.01). There was no significant difference in salivary lysozyme among pupils of different sex and age. Mixed linear model suggested that for 1 μg/m3 increase of PM2.5, PM10, SO2, NO2 and CO, salivary lysozyme increased by 1.75, 0.82, 6.12, 1.05 and 70.73 μg/L,respectively. Salivary lysozyme increased by 8.17 μg/L for 1 μg/m3 increase of SO2 the day before the test. Conclusion The level of salivary lysozyme in pupils is positively correlated with the concentration of air pollutants with a lagging effect.

关 键 词：唾液 酶类 大气 环境污染物 学生 

分 类 号：G637.8[文化科学—教育学] R446[医药卫生—诊断学]