超声波制备肝素苄基酯优化工艺研究  

Study on process optimization of ultrasonic preparation of enoxaparin benzyl ester

作　　者：杨彬[1] 王志耕[1] YANG Bin;WANG Zhi-geng(College of Tea&Food Science,Anhui Agricultural University,Hefei 230036,China)

机构地区：[1]安徽农业大学茶与食品科技学院

出　　处：《应用化工》2019年第12期2859-2863,共5页Applied Chemical Industry

基　　金：国家自然科学基金(31360579)

摘　　要：粗品肝素钠用甲醇提纯,与苄索氯铵反应,得到肝素季铵盐。加入氯化苄,超声反应得到肝素苄基酯。研究超声波功率和酯化反应时间对肝素苄基酯酯化率的影响,结果表明最佳工艺为:温度35~40℃,功率400 W,超声反应时间5.5 h,酯化率达5.35%。Heparin quaternary ammonium salts are obtained by the reaction of heparin sodium purified with methanolwith benzethonium chlorid,then mix with benzyl chloride to obtain heparin benzyl ester under the ultrasonic treatments.The effects of ultrasonic power and esterification reaction time on the esterification rate of enoxaparin benzyl ester were investigated.The results indicated that the optimum temperature ranges 35~40℃,the optimum ultrasonic power is 400 W,and the optimum ultrasonic reaction time is 5.5 h,the esterification rate of ultrasonic assisted preparation is 5.35%.

关 键 词：超声波 肝素苄基酯 多硫酸软骨素 酯化率 优化工艺 

分 类 号：TQ460.31[化学工程—制药化工]