补体介导的肿瘤免疫逃逸及其在免疫检查点抑制剂治疗中的应用  

Complement mediated tumor immune escape and its application in immune checkpoint inhibitorstherapy

作　　者：李可馨 崔巍 Li Kexin;Cui Wei(Department o f Clinical Laboratory,National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital,Chinese Academy o f Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院检验科,北京100021

出　　处：《中华检验医学杂志》2019年第12期981-985,共5页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金面上项目(81772272);中国医学科学院医学与健康科技创新工程项目(2017-I2M-3-005)。

摘　　要：补体系统是固有免疫系统的重要组成部分,目前许多证据表明,补体对机体的作用不仅仅限于清除病原微生物等危险因素,补体还可以通过不同的作用途径影响肿瘤免疫逃逸机制进而参与肿瘤的发生发展。鉴于补体在肿瘤中发挥着复杂且重要的作用,本文分别从补体固有成分、补体活化产物以及补体调节蛋白3个方面阐述补体系统参与肿瘤免疫逃逸的相关机制,并针对这些机制为补体在免疫检査点抑制剂治疗中的应用进行展望,旨在为肿瘤的免疫治疗提供新的方向。The complement system is an important part of the innate immune system.More evidence showed that the function of complement was not only limited to the elimination of pathogens and other risk factors from the body but also affected the immune escape mechanism of the tumor through different activating pathways.Because of the complex and important role of complement in the tumor,this review expounds the mechanism of complement system participating in immune escape of the tumor from three aspects:complement inherent components,complement activation products and complement regulatory proteins.Additionally,these mechanisms are expected to provide a new application of complement in tumor immunotherapy with immune checkpoint inhibitors.

关 键 词：肿瘤逃逸 补体激活 补体系统蛋白质类 免疫抑制剂 免疫疗法 

分 类 号：R73[医药卫生—肿瘤]