磁共振动脉自旋标记技术在早产儿脑灌注中的应用  

Application of Magnetic Resonance Arterial Spin Labeling in Cerebral Perfusion in Preterm Infants

作　　者：高敏[1] 刘玉奇[1] 宋永瑞[1] 吴继志[1] 盛茂[1] GAO Min;LIU Yuqi;SONG Yongrui(Department of Radiology,Childrens Hospital of Soochow University,Suzhou,Jiangsu Province 215000,P.R.China)

机构地区：[1]苏州大学附属儿童医院放射科

出　　处：《临床放射学杂志》2019年第10期1939-1942,共4页Journal of Clinical Radiology

摘　　要：目的应用3D-ASL技术分析不同校正胎龄期早产儿与正常同龄期足月儿不同部位间脑血流量(CBF)的差异以及CBF与校正胎龄的相关性,探讨早产儿脑部灌注的变化。方法对26例早产儿及13例正常足月儿进行头颅常规MRI及3D-ASL检查,获得脑部灌注图像,分别测得双侧额叶白质、基底节及丘脑的CBF值,分析早产儿与足月儿不同部位间CBF的差异以及CBF与校正胎龄之间的相关性。结果校正胎龄<37周早产儿和正常足月儿各部位的相对脑血流量(rCBF)均小于矫正胎龄≥37周早产儿,差异有统计学意义(P<0.05);在各个校正胎龄期,基底节和丘脑的rCBF与额叶白质差异均有统计学意义(P<0.05),基底节和丘脑均大于额叶白质,基底节与丘脑间的rCBF无明显统计学差异(P>0.05)。结论 3D-ASL在评价早产儿脑灌注方面有重要研究价值。Objective To analyze the differences in cerebral blood flow between different corrected gestational age preterm infants and normal term infants with term 3 D-ASL,and to explore the correlation between cerebral blood flow and corrected gestational age,so as to investigate changes in cerebral perfusion in preterm infants. Methods The routine MRI and 3 D-ASL examinations were performed on 26 premature infants and 13 normal full-term infants in our hospital. The brain perfusion images were obtained and the CBF values of the bilateral frontal white matter,basal ganglia and thalamus were measured. The difference in cerebral blood flow between preterm and term infants and the correlation between cerebral blood flow and corrected gestational age was determined. Results The rCBF of the preterm infants corrected gestational age <37 weeks and normal term infants was less than the preterm infants corrected gestational age ≥37 week,the difference was statistically significant(P<0.05). In each corrected gestational age period,the basal ganglia and thalamus had statistically significant differences in rCBF and frontal white matter(P<0.05). The basal ganglia and thalamus were larger than the frontal white matter,and between basal ganglia and thalamus,difference was not statistically significant(P>0.05). Conclusion 3 D-ASL has important research value in evaluating cerebral perfusion in preterm infants.

关 键 词：动脉自旋标记 早产儿 脑血流量 校正胎龄 

分 类 号：R74[医药卫生—神经病学与精神病学]