整合性接合元件SXT-R391分子生物学特性及其转移系统的研究进展  

Research progress in molecular characteristics and transconjugation system of SXT-R391 integrative and conjugative elements

作　　者：贺羽[1] 王帅 李慧[1] 冯小刚[1] 商学兵[1] HE Yu;WANG Shuai;LI Hui;FENG Xiao-Gang;SHANG Xue-Bing(School of Food(Biology)Engineering,Xuzhou University of Technology,Xuzhou,Jiangsu 221111,China)

机构地区：[1]徐州工程学院食品(生物)工程学院

出　　处：《微生物学通报》2019年第12期3424-3431,共8页Microbiology China

基　　金：国家自然科学基金青年项目(31701566);江苏省高校自然科学基金面上项目(18KJB550011);徐州工程学院校级课题(XKY2018248,XKY2019136)~~

摘　　要：整合性接合元件(Integrative and conjugative elements,ICEs)主要介导原核生物间遗传信息的横向基因交换,在细菌毒性、耐药性、抗重金属等特性传播上发挥关键作用。ICEs的水平转移极大地加速了抗性基因在同种及不同种属之间的传播,造成细菌的耐药以至多重耐药问题日益严重,耐药机制日趋复杂;同时ICEs的接合转移过程受细菌Ⅳ型分泌系统(Type Ⅳ secretion system,T4SS)影响。本文着重从ICEs的基因结构、接合转移过程以及T4SS组成元件的结构进行概述,并对T4SS各组件间相互作用的研究进展进行了初步探讨。Integrative and conjugative elements(ICEs) mediate bacteria bestow resistance to multiple antibiotics and some complex new traits through horizontal gene transfer(HGT). They encoded a wide variety of genetic information, including resistance to antibiotics and heavy metals and the capacity to degrade aromatic compounds which are affected by bacterial type Ⅳ secretion system(T4 SS), the transfer of these genetic elements would speed up the dissemination of antibiotic resistance genes within and between microbial genera. It results in the growing problems of drug resistance, even multi-drug resistance and makes the mechanism of resistance become exceedingly complex. In this review, the structure and conjugation process of ICEs and the interactions with the components of T4 SS are discussed.

关 键 词：整合性结合元件 Ⅳ型分泌系统 基因结构 接合转移 

分 类 号：Q78[生物学—分子生物学]