经支气管镜冷冻及高频电灼在中央型肺癌致气道狭窄中的疗效分析  

Analysis of the Effect of Bronchoscopic Cryotherapy and High Frequency Electrocautery on Airway Stenosis Caused by Central Lung Cancer

作　　者：胡莺 陈晓霞 李王平 潘蕾 李春梅 HU Ying;CHEN Xiaoxia;LI Wangping(Tangdu Hospital of Air Force Military Medical University,Shaanxi Xi'an 710028,China)

机构地区：[1]空军军医大学唐都医院呼吸与危重症医学科

出　　处：《河北医学》2019年第12期2079-2082,共4页Hebei Medicine

基　　金：陕西省科学技术研究发展计划项目,(编号:S2015YFSF01408)

摘　　要：目的:探讨经支气管镜冷冻及高频电灼在中央型肺癌致气道狭窄中的疗效。方法:将我院收治的90例中央型肺癌致气道狭窄患者依据治疗方式不同分为高频电灼组(30例,实施经支气管镜高频电灼治疗)、支气管冷冻组(30例,实施经支气管镜冷冻治疗)及联合治疗组(30例,经支气管镜冷冻及高频电灼治疗),观察治疗后三组临床疗效、气促评分、肺功能[用力肺活量(FVC)、第1秒钟用力呼吸量(FEV1)、最大自主通气量(MVV)]。结果:治疗后联合治疗组总有效率较高频电灼组、支气管冷冻组明显高(P<0.05);治疗后三组气促评分较治疗前明显降低,FVC、FEV1、MVV明显升高,且治疗后联合治疗组各项指标变化最大,支气管冷冻组次之,高频电灼组最小,三组之间两两相较差异显著(P<0.05)。结论:经支气管镜冷冻及高频电灼在中央型肺癌致气道狭窄患者中的近期疗效相当,两者联合应用可有效提高临床疗效,并明显改善患者气促症状及肺功能。Objective: To investigate the efficacy of transbronchoscopic cryotherapy and high-frequency electrocautery in treatment of airway stenosis caused by central lung cancer. Methods: 90 patients with airway stenosis caused by central lung cancer were divided into the high-frequency electrocautery group(30 cases treated with transbronchoscopic high-frequency electrocautery). The cryotherapy group(30 cases treated with transbronchoscopic cryotherapy) and the combined group(30 cases treated with transbronchoscopic cryotherapy and high-frequency electrocautery). The clinical effect, shortness of breath score, pulmonary function(FVC, FEV1, MVV) of the three groups were observed. Results: The total treatment effective rate of the combined group was significantly higher than that of high-frequency electrocautery group or the cryotherapy group(P<0.05). After treatment, shortness of breath scores were decreased significantly while FVC, FEV1 and MVV were increased significantly, and changes were the most obvious in the combined group, followed by high-frequency electrocautery group and changes were the smallest in cryotherapy group(P<0.05). Conclusion: The short-term effects of transbronchoscopic cryotherapy and high-frequency electrocautery are similar in treatment of airway stenosis caused by central lung cancer. The combined use can effectively improve the clinical efficacy, significantly relieve shortness of breath and improve lung function.

关 键 词：中央型肺癌 气道狭窄 支气管镜 冷冻 高频电灼 

分 类 号：R734.2[医药卫生—肿瘤]