新型N-吡咯乙酸异丁醇酯的制备及其热行为分析  

Synthesis and thermal behavior analysis for new N-pyrrole acetic acid isobutyrate

作　　者：潘婷婷[1] 艾绿叶 姬小明[2] 龚忠熹 王建玲 PAN Tingting;AI Lüye;JI Xiaoming;GONG Zhongxi;WANG Jianling(Hubei Tobacco Industry Limited Company,Wuhan 430030,China;College of Tobacco Science,Henan Agricultural University,Zhengzhou 450002,China;Facultyof Science,Henan University of Animal Husbandry and Economy,Zhengzhou 450011,China)

机构地区：[1]湖北中烟工业有限责任公司,湖北武汉430030 [2]河南农业大学烟草学院,河南郑州450002 [3]郑州牧业经济学院理学部,河南郑州450011

出　　处：《河南农业大学学报》2019年第6期983-986,1010,共5页Journal of Henan Agricultural University

基　　金：河南省科技厅重点科技攻关项目(152102210059);湖北中烟工业有限责任公司应用科技类项目(2018420000340440)

摘　　要：以2,5-已二酮和甘氨酸为原料进行Paal-Knorr反应,合成2,5-二甲基-N-吡咯乙酸。以其为底物,与异丁醇进行酯化反应,得到目标化合物2,5-二甲基-N-吡咯乙酸异丁醇酯。通过1 HNMR,13 CNMR,IR和HRMS技术对其结构进行表征。采用热裂解-气相色谱/质谱(Py-GC/MS)分析其热解行为。从裂解产物上可知,目标化合物的主要热解成分为杂环及酯类化合物。杂环化合物有2,6-二甲基吡啶、2,5-二甲基吡咯、2-乙基-5-甲基吡嗪等;酯类有十六酸-2-甲基丙酯等。The compound of 2,5-dimethyl-N-pyrrole acetic acid was synthesized by Paal-Knorr reaction using 2,5-hexanedione and glycine as raw materials.The target compound 2,5-dimethyl-N-pyrrole acetic acid isobutyrate was then obtained though esterification from isobutanol and 2,5-dimethyl-Npyrrole acetic acid.1 HNMR,13 CNMR,IR and HRMS spectrometry were employed to analyze the structure of prepared product.Meanwhile,the pyrolysis behavior was also tested by pyrolysis-gas chromatography/mass spectrometry(Py-GC/MS).According to the Py-GC/MS results,the pyrolysis products of target compound were mostly heterocyclic compounds and ester compounds.Among,the heterocyclic compounds included 2,6-lutidine,2,5-dimethylpyrrole,2-ethyl-5-methylpyrazine,etc.And the esters included hexadecanoic acid-2-methylpropyl ester,etc.

关 键 词：Paal-Knorr反应 N-吡咯乙酸异丁醇酯 酯化反应 热行为分析 

分 类 号：TQ655[化学工程—精细化工]