重度阿尔兹海默病患者血脂水平分析  

Changes of Blood Lipid Levels in Patients with Severe Alzheimer′s Disease

作　　者：王鲁妮 黄燕花 WANG Lu-ni;HUANG Yan-hua(Five Departments of the Cadre Ward of the General Hospital of the Southern War Zone of the Chinese People′s Liberation Army,Guangzhou 510010,China)

机构地区：[1]中国人民解放军南部战区总医院干部病房五科

出　　处：《标记免疫分析与临床》2019年第11期1837-1839,共3页Labeled Immunoassays and Clinical Medicine

基　　金：广东省自然科学基金资助项目(编号:s2012010009032)

摘　　要：目的探讨重度阿尔兹海默病(AD)患者的血脂水平。方法选择重度AD患者(MMSE≤5)52例作为观察组,选择同期健康体检老年人40例(MMSE≥23)作为对照组。对比两组简易智能量表(MMSE)和日常生活能力(ADL)量表评分;采用选择抑制法检测两组外周血浆总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平;采用免疫比浊法测定载脂蛋白A(Apo-a)、载脂蛋白B(Apo-b)水平。结果观察组外周血浆TC、TG、HDL-C、LDL-C、Apo-a水平与对照组水平比较差异无统计学意义。观察组Apo-b水平高于健康对照组(1.39±0.25g/L vs 0.78±0.18g/L,t=13.04,P<0.05)。结论 Apo-b水平增高可能促进阿尔兹海默病进展。Objective To observe blood lipid levels in patients with severe Alzheimer′s Disease(AD).Methods 52 patients with severe AD(MMSE≤5)and 40 healthy people(MMSE≥23)from physical examination during the same period from the same hospital were selected as the experimental group and control group,respectively.The cognitive and mobility functions were assessed by mini-mental state examination(MMSE)and activities of daily living(ADL)among all patients.Total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein A(Apo-a)and apolipoprotein B(Apo-b)were compared between the two groups.Results The level of Apo-b in the severe AD group were significantly higher than those in the normal group(1.39±0.25 g/L vs 0.78±0.18 g/L,t=13.04,P<0.05).There was no significant difference for the levels of TC,TG,HDL-C,LDL-C and Apo-a betwen the two groups.Conclusion Apo-b level could contribute to the progression of AD.

关 键 词：重度阿尔兹海默病 高密度脂蛋白胆固醇水平 低密度脂蛋白胆固醇水平 载脂蛋白A 载脂蛋白B 

分 类 号：R74[医药卫生—神经病学与精神病学]