宫颈癌组织中Ep-CAM和Ki67的表达及临床意义  

Expression and Clinicd Value of Ep-CAM and Ki67 in the Cervial Carcinoma Tissue

作　　者：周静[1] 李智 周玉[3] 丁文文 杨雪琴[1] ZHOU Jing;LI Zhi;ZHOU Yu;DING Wen-wen;YANG Xue-qin(Medical School of Jingchu Technology University,Hubei Jingmen 448000,China;Medical Department of Jingmen Dongbao People’s Hospital,Hubei Jingmen 448000,China;Medical Department of Jingmen First People’s Hospital,Hubei Jingmen 448000,China)

机构地区：[1]荆楚理工学院医学院,湖北荆门448000 [2]湖北省荆门市东宝区人民医院医务部,湖北荆门448000 [3]湖北省荆门市第一人民医院医务部,湖北荆门448000

出　　处：《现代检验医学杂志》2019年第6期24-27,共4页Journal of Modern Laboratory Medicine

基　　金：荆门市科技局2018年科研项目(项目编号：2018YFYB047);湖北省高等学校优秀中青年科技创新团队项目(项目编号：T201819)

摘　　要：目的探讨上皮细胞黏附分子(epithelial cellular adhesion molecule,Ep-CAM)和细胞增殖核抗原67(Kiel67,Ki67)在宫颈癌组织中的表达及临床意义。方法选取234例宫颈活检组织,其中宫颈癌组织94例(浸润性鳞癌50例,腺癌44例),鳞状上皮内病变(squamous intraepithelial lesion,SiL)组织90例,其中低级别SiL(low grade squamous intraepithelial lesion,LSiL)45例和高级别SiL(high grade squamous intraepithelial lesion,HSiL)45例,正常宫颈组织50例。分别对上述三类组织进行免疫组化,观察Ep-CAM和Ki67的表达情况。结果 Ep-CAM和Ki67在宫颈癌组织中的阳性率均为100%,高于LSiL和正常宫颈组织,差异均有统计学意义(χ^2=121.473~144.000,均P<0.05);Ep-CAM在浸润性鳞癌中的高表达率高于腺癌,差异有统计学意义(χ^2=4.713,P<0.05),Ep-CAM和Ki67在中晚期宫颈癌组织的高表达率高于早期宫颈癌组织,差异均有统计学意义(χ^2=7.598~9.760,均P<0.05)。结论 EpCAM和Ki67可作为宫颈癌较为理想的肿瘤标志物,尤其是Ep-CAM,能够帮助临床明确细胞的性质,评价肿瘤细胞的增殖状态,同时预测浸润和转移,具有临床应用价值。Objective To explore the expression and the clinic evaluation of Ep-CAM(epithelial cellular adhesion molecule),Ki67(Kiel 67) in cervix carcinoma tissue. Methods 234 cases of cervical biopsy tissue were selected, 94 were cervix carcinoma tissue(50 cases for invasive squamous carcinoma, 44 cases for adenocarcinoma), 90 cases SiL(squamous intraepithelial lesion),45 cases were LSiL(low grade squamous intraepithelial lesion),45 cases were HSiL(high grade squamous intraepithelial lesion) and 50 cases normal cervix tissue. Ep-CAM and Ki67 of all the tissues above were tested by immunohistochemical. Results The positive rate of Ep-CAM, Ki67 in cervix carcinoma were 100%, significantly higher than LSiL and normal cervical tissue(χ^2=121.473~144.000,all P<0.05). Ep-CAM displayed the higher high-expression rate in invasive squamous cell carcinoma than adenocarcinoma(χ^2=4.713,P<0.05), and the high-expression rate of Ep-CAM and Ki67 in advanced cervical cancer were significantly than early cervical cancer(χ^2=7.598~9.760,P<0.05). Conclusion EpCAM and Ki67 can be used as effective tumor markers for cervix carcinoma,especially Ep-CAM, can help to identify the nature of cells,evaluate the proliferative status of cancer cells and predict infiltration and metastasis.So they have clinical application value.

关 键 词：上皮细胞黏附分子(Ep-CAM) 细胞增殖核抗原67(Ki67) 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤] R730.43[医药卫生—临床医学]