原发性肝细胞癌患者TACE治疗前后血清血小板源性生长因子-BB水平变化及其临床意义  

Changes of Serum Platelet-Derived Growth Factor-BB Level before and after TACE Treatment in Patients with Primary Hepatocellular Carcinoma and Its Clinical Significance

作　　者：高云飞[1] 高凤成 李清峰 马强[2] 邢通潮 杜婷婷[4] GAO Yun-fei;GAO Feng-cheng;LI Qing-feng;MA Qiang;XING Tong-chao;DU Ting-ting(Department of Infectious Disease,Yulin First Hospital,Shaanxi Yulin 719000,China;Peripheral Vascular Department,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China;Department of General Surgery,the Fourth People’s Hospital of Shaanxi Province,Xi’an 710043,China;Yan’an People’s Hospital,Shaanxi Yan’an 716000,China)

机构地区：[1]榆林市第一医院感染科,陕西榆林719000 [2]西安交通大学第一附属医院周围血管科,西安710061 [3]陕西省第四人民医院普外科,西安710043 [4]延安市人民医院,陕西延安716000

出　　处：《现代检验医学杂志》2019年第6期73-76,共4页Journal of Modern Laboratory Medicine

基　　金：陕西省卫计委科技计划(2016D065)

摘　　要：目的探讨原发性肝细胞癌(HCC)患者经皮肝动脉化疗栓塞(TACE)治疗前后血清血小板源性生长因子(PDGF)-BB的变化情况及其与近期疗效的关系。方法选取2016年1月~2018年10月采用TACE治疗的172例HCC患者为观察组,另选取同期80例健康体检者作为对照组,采用酶联免疫吸附试验法(ELISA)检测血清中PDGFBB水平。结果观察组患者术前、术后1天、1周和1月的血清PDGF-BB水平均显著高于对照组,差异均具有统计学意义(P<0.01)。TACE术前观察组患者的血清PDGF-BB水平与肿瘤数目、肿瘤大小和有无癌栓相关(P<0.05)。TACE术后观察组患者的疗效与肿瘤数目、肿瘤大小、有无癌栓、术前血清AFP水平和术后1周血清PDGF-BB水平显著相关(均P<0.05)。Logistic多因素分析结果显示术后1周血清PDGF-BB(OR=2.665, 95%CI:1.231~5.769, P=0.000)和肿瘤数目(OR=1.904, 95%CI:1.023~3.544, P=0.005)均是影响TACE术后疗效的因素。结论血清中PDGF-BB水平与TACE术后HCC患者的短期疗效密切相关。Objective To investigate the changes of serum platelet-derived growth factor(PDGF)-BB before and after transcatheter arterial chemoembolization(TACE) in patients with primary hepatocellular carcinoma(HCC) and its relationship with short-term efficacy. Methods A total of 172 HCC patients treated with TACE in their hospital from January 2016 to October 2018 were selected as the observation group, and 80 healthy patients in their hospital during the same period were selected as the control group, and serum PDGF-BB level was detected by ELISA. Results The serum PDGF-BB level in the observation group was significantly higher than that in the control group(P<0.01). The serum PDGF-BB level of patients in the preoperative TACE observation group was correlated with the number of tumors, tumor size and the presence or absence of tumor thrombus(P<0.05). The efficacy of patients in the observation group after TACE was significantly correlated with tumor number, tumor size, tumor embolism, serum AFP level before surgery and serum PDGF-BB level 1 week after surgery(all P<0.05). Logistic multivariate analysis showed that serum PDGF-BB level at 1 week after the operation(OR=2.665, 95% CI: 1.231~5.769, P=0.000) and tumor number(OR=1.904, 95% CI: 1.023~3.544, P=0.005) were both factors affecting the postoperative efficacy of TACE. Conclusion Serum PDGF-BB level is closely related to the short-term efficacy of HCC patients after TACE.

关 键 词：原发性肝细胞癌(HCC) 经皮肝动脉化疗栓塞(TACE) 血小板源性生长因子-BB(PDGF-BB) 

分 类 号：R735.7[医药卫生—肿瘤] R730.43[医药卫生—临床医学]